Proceedings: Effects of interactions of cell cycle-specific cytotoxic drugs and X-radiation on survival of cell reproductive capacity.AnimalsMiceAntineoplastic AgentsRadiation EffectsCell DivisionThe BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and ...
Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo Time-dependent chemotherapeutic agents can selectively target tumor cells in susceptible phases of the cell cycle however a fraction of tumor cells in non-... 被引量: 8发表: 0年 The Immune adjuvant properties of fron...
BioDrugs (2016) Synthesis of novel 5-methyl pyrazol-3-one derivatives and their in vitro cytotoxic evaluation Pritam N. Dube Shweta S. Bule Pravin R. Dighe Medicinal Chemistry Research (2015) CD30 as a Therapeutic Target for Lymphoma Thomas Schirrmann Miriam Steinwand Stefan Barth BioDrug...
In this Review, we survey developments in the field of small ligand‐based targeted cytotoxics and show how innovative library technologies will help develop the drugs of the future. 展开 关键词: cancer DNA‐encoded libraries drug conjugates drug delivery prodrugs ...
Related to cytotoxic cell: CD8+ cellcell an independent team of operatives who work together in a CELLULAR MANUFACTURING production environment. Collins Dictionary of Business, 3rd ed. © 2002, 2005 C Pass, B Lowes, A Pendleton, L Chadwick, D O’Reilly and M AffersonWant...
A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: Similarities and differences to the cell cycle ch... Unfortunately, UCN-01 binds avidly to human plasma proteins, limiting access to the tumor. A screen of related indolocarbazoles identified ...
Cisplatin is one of the most widely used anticancer drugs. Significant side effects and drug resistance have limited the clinical applications of cisplatin. In recent years, the anticancer activity of the ruthenium complexes has been paid great attention. Up to now, two ruthenium complexes NAMI-A ...
In the event of DNA damage, the cell cycle is stalled at the G1/S, intra-S, and G2/M checkpoints. The cell-cycle arrests provide an opportunity for the cells to repair the DNA damage and survive. This mechanism also underlies the cancer resistance to DNA damaging chemotherapy.1 ...
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 25, 1053–1069 (2005). Supplementary information accompanies the paper on The Journal of ...
Cell binding agent conjugates of analogues and derivatives of CC- 1065 The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because they deliver the cytotoxic drugs to a specific cell population in a targeted fashion... RVJ Chari,VS Goldmakher...