网络周期非特异性药物 网络释义 1. 周期非特异性药物 周期非特异性药物(cell cycle non-specific drugs)直接破坏DNA结构以及影响其复制或转录功能的药物,如烷化剂、抗肿瘤抗 … 210.44.16.104|基于8个网页
The possible response of tumor and normal cells under the influence of cycle-specific drugs is formulated as an optimal control problem. The objective is to minimize the tumor burden, with minimum harm to the patient's health. Elitist non-dominated sorting genetic algorithm-II optimizes the drug...
Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids...
Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical pharmacology. Decreased viability of tumor cells may reflect two important physiological processes, namely the arrest of proliferation associated with disturbances in
Y. Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase. Nat. Methods 2, 99–104 (2005). Article CAS PubMed Google Scholar Lin, C. W. & Ting, A. Y. Transglutaminase-catalyzed site-specific conjugation of small-molecule probes to proteins in vitro ...
the presence of specific Cdk inhibitors in the G1 phase prevents activation of Cdks. With the end of mitosis, the Cdk activity is almost absent in the cell. Several mechanisms prevent Cdk reactivation. These give the cell the necessary time to grow before the next cycle of replication and ...
Premo FUCCI cell cycle sensor is designed for live-cell imaging of cell cycle progression and can be used to assess the effect of drugs, siRNA or other factors on the transition of cells through the cell cycle. The...
Under specific microenvironmental stimuli, certain cancer cells exhibit plasticity, which enables them to resume proliferation through EMT [121]. For example, Chang et al [122] revealed that the activation of the Hh signaling pathway in the TME can transform common prostate cells into stem cells. ...
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cyc
MSCs possess the capacity for undergoing self-renewal and the generation of specific differentiated cells, and are gaining interest as a novel cell-based therapy ageinst diabetes [4, 5]. MSCs may be derived from multiple sources including bone marrow, adipose, umbilical cord, menstrual blood and...