Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs is it a new perspective for personalized treatment of cancer patients?doi:10.1080/19490976.2023.2281017Pharmacomicrobiomicscancer patient5-fluorouracilgemcitabinecapecitabinemethotrexateIntestinal bacteria are equipped with an enzyme apparatus that is ...
With regard to cancer therapy, this concept postulates that inhibition of a specific protein is lethal for cancer cells harbouring a particular mutation while sparing normal cells without that mutation. As a result, drugs provoking synthetic lethality are expected to have a higher therapeutic index....
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Notably, drugs targeting CFTR may find application in colorectal cancer. Tezacaftor may have potent anticancer activity against colorectal cancer and improve metastatic processes through its impact on the CFTR gene, consistent with this study. Tétard et al. demonstrated that Lumacaftor/Ivacaftor, CFTR ...
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and clinically explored for the treatment of various diseases, but are often limited by low efficacy and safety concerns. Drug delivery systems at the nanoscale, microsc
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Since HeLa established, immoral cancer cell lines are intensively studied as a biological models to investigate cancers biology (e.g., cancer initiation, progression, metastasis, tumor microenvironment and cancer stem cells) and evolved anticancer drugs or alternative form of therapy, for example, hype...
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Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and availa
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