If 100 cells are examined, the number of cells in each identifiable cell cycle stage will give an estimate of the time it takes for the cell to complete that stage. Problem Statement: Given the events included in all of interphase and those that take place in each stage of mitosis, ...
The possible response of tumor and normal cells under the influence of cycle-specific drugs is formulated as an optimal control problem. The objective is to minimize the tumor burden, with minimum harm to the patient's health. Elitist non-dominated sorting genetic algorithm-II optimizes the drug...
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to ...
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to met...
Chemical inhibition has emerged as a powerful approach to advance our understanding of these mitotic kinases, and numerous inhibitors are being developed as potential anticancer drugs. Other cell cycle regulators, such as the DNA damage checkpoint kinases and spindle-assembly checkpoint proteins, are ...
Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids...
Importantly, in some cases the continued presence of a cell cycle protein has also been shown to be required for tumour maintenance and progression, for example, for cyclin D1, cyclin D3 and CDK4, thereby providing a clear rationale for targeting these proteins in cancer treatment. Kinases ...
The cell cycle and cancer chemotherapy. Bingham CA. CA Bingham - 《American Journal of Nursing》 被引量: 9发表: 1978年 Newer concepts of cancer of the colon and rectum: Cell kinetics, chemotherapy, and colonic cancer Newer concepts of cancer of the colon and rectum: Cell kinetics, chemothera...
C. The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies. Nat. Immunol. 21, 835–847 (2020). Article CAS PubMed PubMed Central Google Scholar Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. ...
[84]. An elevated cell proliferation rate and cell cycle abnormalities have been reported to be caused by inactivation of tumor suppressor genes such as CDKN2A, PTEN and TP53 [85,86]. Because the induction of apoptosis alone via traditional anticancer therapeutic strategies does not completely ...