Cell-cycle-dependent drug-resistant quiescent cancer cells induce tumor angiogenesis after chemotherapy as visualized by real-time FUCCI imaging. Cell Cycle 2017, 16, 406-414. [CrossRef] [PubMed]Yano S, Takehara K, Tazawa H, et al. Cell-cycle-dependent drug-resistant quiescent cancer cells ...
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to ...
Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an important source of relapse following chemotherapy. We postulated that cell-cycle kinetics of pre-LSCs may be an important determinant of clonal evolution and therapeutic r...
aHard to avoid blame time hand and fell in love in. 艰苦避免责备时间手和坠入爱河in。[translate] aIn summary, we demonstrate, for the first time, that 总之,我们展示,第一次,那[translate] achemotherapy, via suppressing cell cycle progression and 正在翻译,请等待...[translate]...
A family of proteins that are involved in cell cycle progression. They are transiently expressed in response to growth signals in order to regulate the timely activation of cyclin-dependent kinases. Cell cycle checkpoints A series of surveillance pathways which ensure that cells pass accurate copies...
Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied ... P Smith,S Sou...
Homologous cancer cell membrane-camouflaged nanoparticles target drug delivery and enhance the chemotherapy efficacy of hepatocellular carcinoma. Cancer Lett. 2023;558: 216106. Article CAS PubMed Google Scholar Xu L, Wu S, Wang J. Cancer cell membrane–coated nanocarriers for homologous target ...
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network c
Chemotherapy triggers hif-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112(33):E4600–9. Article PubMed PubMed Central Google Scholar Lin Z, Song J, Gao Y, Huang S, Dou R, Zhong P, et al...
In this Review, we focus on proteins that directly regulate cell cycle progression (such as cyclin-dependent kinases (CDKs)), as well as checkpoint kinases, Aurora kinases and Polo-like kinases (PLKs). We discuss the role of cell cycle proteins in cancer, the rationale for targeting them ...