aHard to avoid blame time hand and fell in love in. 艰苦避免责备时间手和坠入爱河in。 [translate] aIn summary, we demonstrate, for the first time, that 总之,我们展示,第一次,那 [translate] achemotherapy, via suppressing cell cycle progression and 正在翻译,请等待... [translate] ...
cell cyclecancer chemotherapycheck pointsp53cdc2cell deathcytoxicityAs detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human...
We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy...
1-尾- d -Arabinosyl cytosine and methotrexate were studied for their antitumor activity in acute myeloid leukemia of the BN rat (BNML), which is characteri... M Aglietta,P Sonneveld - 《Cancer Chemotherapy & Pharmacology》 被引量: 27发表: 1978年 The cell cycle and cancer chemotherapy. Bin...
Regarding drug mechanism of action, perifosine potentiated the pro-apoptotic effects of paclitaxel, independently of cell cycle arrest, and combining paclitaxel/perifosine resulted in a sustained suppression of glycolytic and mitochondrial metabolism. This study points out that targeting cancer cell ...
Moreover, drug class enrichment analysis of datasets from the LINCS L1000 project37 revealed that PD-L2 is upregulated by known inducers of cellular senescence, such as DNA damage agents and cell cycle inhibitors (Extended Data Fig. 1a). Indeed, PD-L2 transcript levels were upregulated in ...
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Onocase cancer therapy has been seen toreduce cell replication and spread and result in cytotoxic (cell death) effects.It interferes with cell-cycle regulation, which is the process by which cells divide and replicate, and induces programmed cell death (apoptosis). ...
Next, we examined the cell cycle status of Mda5−/− HSCs. When compared to the WT, the BM of Mda5−/− mice had significantly more quiescent (cells in G0) HSCs after treatment with 5-FU, but also at steady state (Fig. 3g and Extended Data Fig. 3e). This steady-state phen...