This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.
The relationships among adult neurogenesis, antidepressant drugs, and depression have generated considerable interest and controversy (Duman, 2004; Scharfman and Hen, 2007). p21Cip1, a cyclin-dependent kinase inhibitor, restrains cell-cycle progression and proliferation. It is found in neuro- blasts ...
Screening for effective chemotherapeutic drugs and improving sensitivity to radiotherapy are hot research topics in current cancer research. Our previous study results have indicated that S109, a novel reversible inhibitor of CRM1, effectively inhibits the growth of GBM cells and prolongs the survival ...
Premo FUCCI cell cycle sensor is designed for live-cell imaging of cell cycle progression and can be used to assess the effect of drugs, siRNA or other factors on the transition of cells through the cell cycle. Th...
Evaluation of the impact of the application of the SNAI1 inhibitor on the tumor microenvironment through scRNA-seq. a. UMAP plot representing non-tumor mouse cells (dots) derived from PDX models of thymic squamous cell carcinoma, with color-coding based on global cell types. b. Relative cellula...
北京时间2024年1月5日,复宏汉霖自主研发的抗PD-1单抗H药 汉斯状®(斯鲁利单抗)联合化疗一线治疗晚期鳞状非小细胞肺癌(sqNSCLC)的注册性III期临床试验(ASTRUM-004)数据在肿瘤学国际顶级期刊Cancer Cell(影响因子:50.3)正式发表,为H...
GO enrichment analysis revealed that these key genes are mainly distributed in the extracellular matrix and spindle and participate in the cell processes such as chromatid separation, cell cycle, mitosis, etc. By binding with chemokine receptors or regulating protein kinase (Fig. 2C-E). In ...
AlexandrouC,Al-AqbiSS,HigginsJA,BoyleW,KarmokarA,AndreadiC,etal.Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.Sci Rep.2018;8:12096. DasK,ButlerGH,KwiatkowskiV,ClarkADJr,YadavP,ArnoldE.Crystal structures of arginine deiminas...
M. et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest. N. Drugs 32, 825–837 (2014). CAS Google Scholar Schulze, V. K. et al. Treating cancer by spindle ...
M. et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest. New Drugs 32, 825–837 (2014). Article PubMed PubMed Central CAS Google Scholar Yadav, V. et al. The CDK...