Background Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in initiating antitumor immune responses and relicensing of anti-tumor cytotoxic T lymphocytes within the tumor microenvironment. Talimogene laherparepvec (T-VEC) induces immunogenic cell death, thereby providing maturation...
FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo. J Immunol. Feb 15;192(4):1982-9. doi: 10.4049/jimmunol.1302391. Epub 2014 Jan 22.Ding Y, ... Vuckovic,Khalil,O'Keeffe,... - 《Journal of Immunology Off...
Background The presence of CD1c (BDCA-1)+ (cDC2) and CD141 (BDCA-3)+ (cDC1) conventional dendritic cells (myDC) in the tumor microenvironment (TME) is a necessary prerequisite to induce an effector CD8+ T cell response and for response to immune checkpoint blockade (ICB).1-4 AS01B...
An independent whole blood single-cell RNA sequencing of COVID-19 patients demonstrated that the monocyte-dendritic cell (Mono-DC) wing was the major cellular source of SRC, among which the higher expression of the SRCs in the monocyte was associated with the asymptomatic COVID-19 patients, ...
Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease. AJP: Renal Physiology. 2013; 305(10):F1391-F401.Kassianos AJ, Wang X, Sampangi S et al. Increased tubulointerstitial recruitment of human CD...
Baseline tumor biopsies from patients who responded to treatment had features of T-cell exclusion. During treatment, there was an increased T-cell infiltration, with a reduced mean distance between T cells and tumor cells. Peripheral blood immune cell composition did not significantly change during ...
CD1c(BDCA-1)+/CD141(BDCA-3)+ myeloid dendritic cells (myDC) in the tumor microenvironment are indispensable at initiating effector T-cell responses and response to ICB. Methods: In this phase II clinical trial, anti-PD-1 ICB pretreated oligometastatic patients (tumor agnostic) underwent a ...