CD141+ CLEC9A+ dendritic cells are enriched in an active state in the inflamedsy- novium and contribute to synovial inflammation in rheumatoid arthritis. Ann Rheum Dis (2016) 75:A3-4. doi:10.1136/annrheumdis-2016-209124.8
CLEC9Adendritic cellsvaccinesWilms' tumor 1Objectives Vaccines that prime Wilms' tumor 1 (WT1)鈥恠pecific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C鈥恡ype lectin...
Staining of normal human peripheral blood cells with Anti-Human CD11c eFluor® 450 (Product # 48-0116-42), Anti-Human CD370 (Clec9A) PE (Product # 12-3709-42), and Mouse IgG2a K Isotype Control APC (Product # 17-4724-42) (left) or Anti-Human CD141 APC (17-1419-42) (right)....
These cells co-express the dead cell receptor C-type lectin domain family 9 member A (CLEC9A) and have variable expression of the tolerogenic molecules immunoglobulin-like transcript (ILT)3 and ILT4. They respond to poly(I:C) by secreting IL-1β and IFN-λ, and can effectively drive T ...
Supernatants from DC-T cell cocultures were used to treat synovial fibroblasts and the expression of adhesion molecules, cytokines and MMPs was measured. CD141 + DC were also identified in synovial-tissue by immunohistology/flow cytometry for CD141/CLEC9A/TREM-1. Finally using sorted populations ...
Increased tubulointerstitial recruitment of human CD141hi CLEC9A þ and CD1c þ myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease. Am J Physiol Renal Physiol 2013; 305: F1391-F1401.Kassianos AJ, Wang X,Sampangi S, et al. Increased tubu-lointerstitial recruitment ...
Staining of normal human peripheral blood cells with Anti-Human CD11c eFluor® 450 (Product # 48-0116-42), Anti-Human CD370 (Clec9A) PE (Product # 12-3709-42), and Mouse IgG2a K Isotype Control APC (Product # 17-4724-42) (left) or Anti-Human CD141 APC (17-1419-42) (right)....
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement Blood, 112 (2008), pp. 3264-3273 View PDFView articleCrossrefView in ScopusGoogle Scholar Chu et al., 2012 C.C. Chu, N. Ali, P. Karagiannis, P. Di Meglio, A. Skowera, L. Napolitano, G...
Staining of normal human peripheral blood cells with Anti-Human CD11c eFluor® 450 (Product # 48-0116-42), Anti-Human CD370 (Clec9A) PerCP-eFluor® 710 (Product # 46-3709-42), and Mouse IgG2a K Isotype Control PE-Cyanine7 (Product # 25-4724-81) (left) or Anti-Human CD141 ...