Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+(DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic ...
ARTICLES nature publishing group CD103 À CD11b þ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin SM Atif1, S Uematsu2, S Akira2 and SJ McSorley1 Toll-like receptor 5 (TLR5) has been widely studied in an inflammatory context, but the effect of...
ARTICLES nature publishing group OPEN Intestinal CD103 þ CD11b À dendritic cells restrain colitis via IFN-g-induced anti-inflammatory response in epithelial cells ARBM Muzaki1,3, P Tetlak1,3, J Sheng1, SC Loh1, YA Setiagani1, M Poidinger2, F Zolezzi2, K Karjalainen1 and C Rue...
CD103+CD11b+dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFβR1) has an indispensable, cell intrinsic role in the development of these cells. Deletion ofTgfbr1results in ...
CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin. Atif SM,Uematsu S,Akira S,et al.CD103-CD11b+dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin.Mucosal Immunol. ... SM Atif,S Uematsu,S Akira,... -...
ARTICLES OPEN CD103 þ CD11b þ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin A Flores-Langarica1, K Mu¨ller Luda2, EK Persson2, CN Cook1, S Bobat1, JL Marshall1, MW Dahlgren2, K Ha¨gerbrand2, KM Toellner1, MD Goodall1, DR Withers1...
Oral APCs were classified into macrophages, classical dendritic cells (cDCs), and Langerhans cells by flow cytometry. A major subset of oral cDCs with the CD103−CD11b+ phenotype showed retinoic acid (RA)-producing activity and converted naive CD4+ T cells to Foxp3+ Treg cells in a ...
Our findings reveal that CD103+CD11b+DCs and the intestinal microbiome are a prerequisite for the activation of intestinal monocytes and macrophages and for dysregulating intestinal motility in POI. 展开 关键词: Postoperative Ileus Immunity Microbiota Intestinal Monocytes and Macrophages, Dendritic cells ...
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity. 2013;38:958–69.Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. ... Andrew,C.,Melton,... - 《Journal of Clinical Investigation》...
T cell CD103– 81.5 CD11b+ 56.9 CD8α+ 27.8 80 70 60 50 40 30 20 10 0 1:8 CD103– 72.1 * 1:16 DC:T cell CD11b+ 66.6 CD103– CD11b+ CD8α+ * 1:32 CD8α+ 73.9 CFSE CFSE Figure 2 Subsets of lymph-borne dendritic cells (LDCs) prime and cross-prime naive T cells with ...