Dendritic cellsMucosal immunologyAntibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+(DP), classical dendritic cells (cDCs) in the induction of...
ARTICLES nature publishing group CD103 À CD11b þ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin SM Atif1, S Uematsu2, S Akira2 and SJ McSorley1 Toll-like receptor 5 (TLR5) has been widely studied in an inflammatory context, but the effect of...
ARTICLES nature publishing group OPEN Intestinal CD103 þ CD11b À dendritic cells restrain colitis via IFN-g-induced anti-inflammatory response in epithelial cells ARBM Muzaki1,3, P Tetlak1,3, J Sheng1, SC Loh1, YA Setiagani1, M Poidinger2, F Zolezzi2, K Karjalainen1 and C Rue...
CD103+CD11b+dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFβR1) has an indispensable, cell intrinsic role in the development of these cells. Deletion ofTgfbr1results in ...
CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellinCD103+CD11b+ mucosal classical dendritic c ...doi:10.1038/mi.2017.105Flores-Langarica, AMüller Luda, KPersson, E KCook, C NBobat, S...
Dendritic cells are key to the initiation and regulation of immune responses. In the gut there are three distinct dendritic cell (DC) subsets, defined by CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has described a role for the...
Figure 2. Subsets of lymph-borne dendritic cells (LDCs) prime and cross-prime naive T cells with different efficiencies. CD103−, CD103+ CD11b+, and CD103+ CD8α+ LDCs were sorted by fluorescence-activated cell sorter and incubated for 2 h with 2 mg ml−1 of ovalbumin protein. DCs...
Batf3-dependent CD103 + CD11b-dendritic cells are crucial for the development of primary biliary cholangitisdoi:10.1016/S0168-8278(18)31139-5D. ReuveniS. AssiP. LeungO. ShiboletE. ZigmondJournal of Hepatology
Figure 1. CD64−CD103−CD11b+ intestinal mononuclear phagocytes (MPs) are bona fide dendritic cells (DCs). (a) Intestinal MPs were defined as CD11c+MHCII+ cells among live CD45+ lamina propria cells, analyzed for CD103 and CD11b expression, and the resulting populations of MP were ex...
2,3 and WW Agace1 Small intestinal lamina propria (SI-LP) CD103+ dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and 4 7 on responding T cells. ...