Accordingly, among antigen-presenting cells, cDC1s exhibited notable induction of IFN-纬 production by iNKT cells, which plays a metabolically protective role in lean adipose tissue. Flt3L treatment, which expand
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tumor T cell memory that prevents cancer relapse. ...
cDC1 在诱导 T 细胞效应反应上优于 cDC2:研究人员通过优化体外抗原暴露和免疫刺激时间,发现 cDC1 在激活肿瘤抗原特异性 CD4+Th1 和 CD8+T 细胞效应反应方面比 cDC2 更有效。例如,cDC1 在与肿瘤细胞裂解物(TCL)和 Toll 样受体(TLR)激动剂孵育 1 小时后,能最有效地促进 OT - I 细胞增殖,而 cDC2 在孵育 ...
cell abundance and favorable prognosis of cancer patients31,32. The pre-clinical effectiveness of transfer of in vitro-generated cDC1-like cells outperforms that of moDCs33and does not rely on host cDCs24. The efficacy of natural splenic cDC1-based vaccination to reduce cancer progression was d...
Conventional dendritic cells (cDCs) are antigen-presenting cells specialized in naïve T cell priming. Mice splenic cDCs are classified as cDC1s and cDC2s, and their main functions have been elucidated in the last decade. While cDC1s are specialized in priming type 1 helper T cells (TH1) an...
Dendritic cells (DCs) play a central role in initiating and regulating immune responses to foreign and self-antigens.1 Under steady-state conditions, lymphoid and nonlymphoid tissues contain stable numbers of DCs, which is achieved through a dynamic interplay between the influx of new precursors, ...
Background Conventional dendritic cells (cDC) are critical mediators of protective anti-tumor CD8 + T-cell responses. 1 Batf3-driven DC1 are the predominant cDC subset driving anti-tumor immunity due to their specialized ability to cross-present antigens for T-cell activation. 2–4 However, the...
While the discovery of unconventional myosins raised expectations that their actions were responsible for most aspects of actin-based cell motility, few anticipated the wide range of cellular functions that would remain the purview of conventional two-headed myosins. The three nonsarcomeric, cellular ...
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer. Howev
Our understanding of conventional dendritic cell (cDC) development and the functional specializations of distinct subsets in the peripheral tissues has increased greatly in recent years. Here, we review cDC development from the distinct progenitors in th