Furthermore, machine learning identified dendritic cells (DCs) as the most discriminative immunocytes in AA and COVID-19. Among five DC subtypes, only conventional dendritic cell 2 (cDC2) exhibited differential expression between AA/COVID-19 and controls (P < 0.05). Subsequen...
Striking a balance: new perspectives on homeostatic dendritic cell maturation Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell responses and immature DCs promote tolerance. Recent studies have shown instead that...
As most of our work on DC ontogeny stems from studies in adult mice, we next confirmed that DNGR-1-expressing cDC progenitors were present in early life bone marrow and spleen. Cells resembling macrophage dendritic cell progenitors (MDPs) (lineage (lin)−CD11c−MHCII−CD11blowCD115+CD13...
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation We have quantified the relative contribution of donor antigen-presenting cell populations to alloantigen presentation after bone marrow transplantation (BM......
In this study, we investigated the interaction between highly purified dendritic cell subsets and EVs derived from amniotic fluid stem cell lines (HAFSC‐EVs). Our results suggest that HAFSC‐EVs are preferentially taken up by conventional dendritic cell type 2 (cDC2) through CD29 receptor‐...
Broggi A, Zanoni I, Granucci F (2013) Migratory conventional dendritic cells in the induction of peripheral T cell tolerance. J Leukoc Biol 94: 903-911.Broggi A, Zanoni I, Granucci F. Migratory conventional dendritic cells in the induction of peripheral T-cell tolerance. J Leukoc Biol (2013...
Conventional type 1 dendritic cells CTL: Cytotoxic T lymphocyte DAMP: Damage associated molecular pattern DEX: Dexamethasone DC: Dendritic cells DOX: Doxycycline ELISA: Enzyme-linked immunosorbent assay ICD: Immunogenic cell death ICI: Immune checkpoint inhibitor iniDC: Induced immortalized ...
Dendritic cells (DCs) are highly potent initiators of adaptive immune responses and, as such, represent promising tools for immunotherapeutic applications. Despite their potential, the current efficacy of DC-based immunotherapies is poor. CD137 ligand (CD137L) signaling has been used to derive a ...
Cutting edge: Conventional CD8alpha + dendritic cells are generally involved in priming CTL immunity to viruses. J. Immunol. 2004; 172 :1996–2000. doi: 10.4049/jimmunol.172.4.1996. [ Cross Ref ]Belz, GT, Smith, CM, Eichner, D, Shortman, K, Karupiah, G, Carbone, FR, ...
Conventional dendritic cells (cDC) are professional antigen-presenting cells that induce immune activation or tolerance. Two functionally specialised populations, termed cDC1 and cDC2, have been described in humans, mice, ruminants and recently in pigs. Pigs are an important biomedical model species ...