Understanding the ontogeny of conventional dendritic cells (cDCs) is a major aim in the field. The fate of progenitors of the recently described subsets of mouse cDC2s (cDC2A and cDC2B) is determined in the bone marrow. Charles-Antoine Dutertre ...
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conven...
Dendritic CellsNKTObesityageingFLT3LConventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic signals.While cDCs are critical in maintaining immune balance,their role in preserving energy homeostasis is unclear.Here,we showed that Batf3-defici...
For example, it remains unclear whether the different subsets described, such as the CD103 + CD11b + and CD103 - CD11b + cDCs in the intestines, truly represent different populations or rather distinct developmental or activation stages. Furthermore, whether distinct progenitors exist for these ...
Interestingly, however, depletion of cDCs significantly improved reduction in fractional shortening. Moreover, fibrosis and cell areas were reduced in infarcted zones. This correlated with reduced numbers of cardiac macrophages, neutrophils, and T cells, indicating a blunted inflammatory response. ...
[Introduction] Dendritic cells (DCs) play a central role in initiation and regulation of immune response. Human plasmacytoid DCs (pDCs) as well as conventional DCs (cDCs) were shown to differentiate from multi-lymphoid progenitors (MLPs) as well as myeloid progenitors via common DC progenitors. ...
In recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing t... A Bachem,S Güttler,E Hartung,... - 《Journal of Experimental Medicine》 被引量: 1422发表: 2010年 Dendritic Cell and Macrophage ...
Of particular importance, CD137L-DCs were found to be more efficient than cDCs in activating autologous T cells targeting the cytomegalovirus (CMV)-derived protein pp65. Specifically, CD137L-DC-stimulated T cells were found to secrete higher levels of IFNγ and killed 2–3 times more HLA-...
CONVENTIONAL DENDRITIC CELLS cDCs have been historically subdivided into many subsets. The exact number of subsets in each tissue is largely dependent on the ''standard'' practice for that tissue.29 In the murine spleen it is common to use CD4 and CD8a to define cDC subsets, which results in...
Classical or conventional dendritic cells (cDCs) are potent activators of naive T cells that have successfully been targeted to induce adaptive immune responses in adults5,6,7,8. In early life, however, these cells are considered under-developed or functionally immature. In murine and human neonat...