The use of dendritic cell (DC)-based cancer vaccines over three decades has shown them to be a safe therapeutic approach against a range of hematological and solid malignancies. However, underwhelming and inconsistent results from clinical trials have seen them move in and out of favor. The ...
Conventional dendritic cells (cDCs) are specialized in antigen presentation. In the mouse spleen, cDCs are classified in cDC1s and cDC2s, and express DEC205 and DCIR2 endocytic receptors, respectively. Monoclonal antibodies (mAbs) αDEC205 (αDEC) and αDCIR2 have been fused to different ...
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tumor T cell memory that prevents cancer relapse. ...
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conven...
1 J Banchereau, RM Steinman Dendritic cells and the control of immunity Nature, 392 (6673) (1998), pp. 245-252 View in ScopusGoogle Scholar 2 J Diao, E Winter, C Cantin, et al. In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in...
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204, 171-180The mononuclear phagocyte (MP) system is a body-wide macrophage (MPhi) and dendritic cell (DC) network,... V Chen,L Landsman,DK Fogg,... - 《Journal of Experimental Medicine》 被...
Programmed cell death protein 1 Poly (I:C) Polyinosinic:polycytidylic acid STAT6 Signal transducer and activator of transcription 6 1. Introduction Conventional Dendritic cells (cDCs) link the innate and the adaptive immune systems. They play an important role in immune surveillance, as they can se...
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responsesCD137 H Schwarz,Z Harfuddin,S Kwajah,... - 《Oncoimmunology》 被引量: 0发表: 2019年 Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immun...
Jun-amino-terminal kinase (SAPK/JNK, JNK1/2) (Thr 183 /Tyr 185 ) mAb (G9), anti-phospho-Akt (Ser 473 ) mAb (193H12) and anti-GAP- DH Ab were purchased from Cell Signaling Technology (Beverly, MA). Anti-phospho-STAT4 (Tyr ...
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer. However, whether oncogenic BCL9/BCL9L impairs...