treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent manner.This effect was partially mediated by NK1.1+cells.These results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue ...
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conven...
Conventional dendritic cells (cDCs) are specialized in antigen presentation. In the mouse spleen, cDCs are classified in cDC1s and cDC2s, and express DEC205 and DCIR2 endocytic receptors, respectively. Monoclonal antibodies (mAbs) αDEC205 (αDEC) and αDCIR2 have been fused to different ...
Moreover, in the course of ICD, cancer cells emit a characteristic array of damage-associated molecular patterns (DAMPs), that act as adjuvants on innate pattern recognition receptors (PRRs) expressed by antigen-presenting cells (APCs) of the conventional dendritic cell (DC) type 1 (cDC1) [...
Striking a balance: new perspectives on homeostatic dendritic cell maturation Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell responses and immature DCs promote tolerance. Recent studies have shown instead that...
The aged tumor microenvironment limits T cell control of cancer Altered natural killer cell鈥揹endritic cell鈥揅D8+T cell cross-talk in aged tumors impairs T cell priming by conventional type 1 dendritic cells and ... ACY Chen,S Jaiswal,D Martinez,... - 《Nature Immunology》 被引量: 0发...
Diet-Induced Obesity Alters Dendritic Cell Function in the Presence and Absence of Tumor Growth Obesity is a mounting health concern in the United States and is associated with an increased risk for developing several cancers, including renal cell car... BR James,A Tomanek-Chalkley,EJ Askeland,...
Broggi A, Zanoni I, Granucci F (2013) Migratory conventional dendritic cells in the induction of peripheral T cell tolerance. J Leukoc Biol 94: 903-911.Broggi A, Zanoni I, Granucci F. Migratory conventional dendritic cells in the induction of peripheral T-cell tolerance. J Leukoc Biol (2013...
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer. However, whether oncogenic BCL9/BCL9L impairs...
Our understanding of conventional dendritic cell (cDC) development and the functional specializations of distinct subsets in the peripheral tissues has increased greatly in recent years. Here, we review cDC development from the distinct progenitors in th