Conventional dendritic cells (cDCs) are innate immune cells. The term cDC refers to all DCs other than plasmacytoid DCs. They reside in tissues and, following tissue infection or injury, they become activated and migrate to draining lymph nodes to promote adaptive immune responses. ...
In solid tumors, CD141conventional dendritic cells (CD141cDCs) are necessary for antitumor immunosurveillance and the response to immunotherapy. Here, we found that CD141cDCs are reduced in MDS bone marrow and based on the premise established in solid tumors, we hypothesized that reduced numbers ...
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conven...
Conventional dendritic cells (cDCs) are specialized in antigen presentation. In the mouse spleen, cDCs are classified in cDC1s and cDC2s, and express DEC205 and DCIR2 endocytic receptors, respectively. Monoclonal antibodies (mAbs) αDEC205 (αDEC) and αDCIR2 have been fused to different ...
Broggi A, Zanoni I, Granucci F (2013) Migratory conventional dendritic cells in the induction of peripheral T cell tolerance. J Leukoc Biol 94: 903-911.Broggi A, Zanoni I, Granucci F. Migratory conventional dendritic cells in the induction of peripheral T-cell tolerance. J Leukoc Biol (2013...
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have...
Dendritic Cell Development from Common Myeloid Progenitors Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It ha... MARKUS,G.,MANZ,... - 《Annals of the New York Academy of Sciences》 被引量: ...
Myeloid dendritic cells (mDCs) are the antigen-presenting cells best capable of promoting peripheral induction of regulatory T cells (Tregs), and are among the first targets of HIV. It is thus important to understand whether HIV alters t... Presicce,Pietro,Moreno-Fernandez,... - 《Plos One...
Dendritic cells (DCs) are highly potent initiators of adaptive immune responses and, as such, represent promising tools for immunotherapeutic applications. Despite their potential, the current efficacy of DC-based immunotherapies is poor. CD137 ligand (CD137L) signaling has been used to derive a ...
REVIEW Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues D Sichien1,2, BN Lambrecht1,3,4, M Guilliams1,2 and CL Scott1,2 Our understanding of conventional dendritic cell (cDC) development and the functional specializations of...