Striking a balance: new perspectives on homeostatic dendritic cell maturation Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell responses and immature DCs promote tolerance. Recent studies have shown instead that...
Macrophages and dendritic cells (DCs) are well equipped to sense environmental cues and play dominant roles in tissue homeostasis and inflammation. Macrophages comprise the most abundant leukocyte population in the adipose stromal fraction, and their number increases with increasing adiposity in both mice...
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have...
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation We have quantified the relative contribution of donor antigen-presenting cell populations to alloantigen presentation after bone marrow transplantation (BM......
内容提示: ArticleType I interferon activates MHC class I-dressedCD11b + conventional dendritic cells to promoteprotective anti-tumor CD8 + T cell immunityGraphical abstractHighlightsd IFN-I induces a stimulatory DC2 state (ISG + DCs) thatactivates CD8 + T cellsd B2M ?/? ISG + DCs acquire ...
In addition, also CD11c + cells, which do not express CD23, are required for IgE-mediated enhancement of T cell responses. This suggests that some type of dendritic cell obtains IgE-Ag complexes from B cells and presents antigenic peptides to T cells. To elucidate the nature of this ...
Selectiveregulationofinterleukin-10productionviaJanuskinasepathwayinmurineconventionaldendriticcellsNoriyukiHirata,YoshikiYanagawa*,KazuyaIwabuchi,Kazunor..
Myeloid dendritic cells (mDCs) are the antigen-presenting cells best capable of promoting peripheral induction of regulatory T cells (Tregs), and are among the first targets of HIV. It is thus important to understand whether HIV alters t... Presicce,Pietro,Moreno-Fernandez,... - 《Plos One...
Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity.Nature392, 245–252 (1998). CASPubMedGoogle Scholar Bain, C.C.et al. Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors.Mucosal...
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual...