Conventional dendritic cells (cDCs) are innate immune cells. The term cDC refers to all DCs other than plasmacytoid DCs. They reside in tissues and, following tissue infection or injury, they become activated and migrate to draining lymph nodes to promote adaptive immune responses. ...
Dendritic cells (DCs) are key regulators of the immune system that shape T cell responses. Regulation of T cell induction by DCs may occur via the intracellular enzyme indoleamine 2,3ヾioxygenase 1 (IDO), which catalyzes conversion of the essential amino acid tryptophan into kynurenine. Here, ...
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual...
Dendritic cells (DCs) are essential orchestrators of immune responses and represent potential targets for immunomodulation in autoimmune diseases. Human amniotic fluid secretome is abundant in immunoregulatory factors, with extracellular vesicles (EVs) being a significant component. However, the impact of th...
Subset‐dependent modulation of dendritic cell activity by circovirus type 2 Viral interactions with dendritic cells (DCs) have important consequences for immune defence function. Certain single-stranded DNA viruses that associate w... IE Vincent,CP Carrasco,L Guzylack-Piriou,... - 《Immunology》 被...
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have...
Dendritic Cell Development from Common Myeloid Progenitors Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It ha... MARKUS,G.,MANZ,... - 《Annals of the New York Academy of Sciences》 被引量: ...
dendritic cellsmonoclonal antibodiesConventional dendritic cells (cDCs) are specialized in antigen presentation. In the mouse spleen, cDCs are classified in cDC1s and cDC2s, and express DEC205 and DCIR2 endocytic receptors, respectively. Monoclonal antibodies (mAbs) αDEC205 (αDEC) and αDCIR2 ...
Dendritic cells (DCs) are highly potent initiators of adaptive immune responses and, as such, represent promising tools for immunotherapeutic applications. Despite their potential, the current efficacy of DC-based immunotherapies is poor. CD137 ligand (CD137L) signaling has been used to derive a ...
Lewis, K.L.et al. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.Immunity35, 780–791 (2011). CASPubMedPubMed CentralGoogle Scholar Cerovic, V.et al. Lymph borne CD8a+ DCs are uniquely able to cross-prime CD8+ T cells with antig...