CD1C是一种转膜蛋白,属于免疫球蛋白超家族的一员,它在人类免疫系统中发挥着重要的作用。 CD1C属于CD1家族,包括CD1A、CD1B、CD1C和CD1D四个亚型,它们在免疫系统中都扮演着不同的角色。与其他CD1家族成员不同的是,CD1C主要表达在树突状细胞(dendritic cells,DCs)和B细胞上。DCs是一类免疫细胞,能够与T细胞相互...
Dendritic cells (DCs) comprise a heterogeneous group of antigen-presenting cells with many specialized functions, including essential constitutive roles in priming immune and autoimmune responses and in the maintenance of peripheral self-tolerance. At the interface of the innate and adaptive immune ...
6 reagents referenced in Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets. Human blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers C... Diego,Piccioli,Simona,... - 《Blood》 被...
16,17 Here we show that CD1c+ blood dendritic cells (DCs) are alternative LC precursors that achieve higher levels of langerin, CD1a, and Birbeck granules than CD14+ monocytes when exposed to soluble factors known to drive LC differentiation. Methods Blood mononuclear cells were obtained from ...
Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined. Methods: EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion ...
Description: This L161 monoclonal antibody detects CD1c (also known as BDCA-1), a glycoprotein that is noncovalently linked to beta-2 microglobulin on thymocytes and antigen presenting cells such as dendritic and Langerhans cells. This molecule is also expressed on some circulating and marginal zo...
Figure 4. Blockade of programmed cell death ligand 1 (PD-L1) enhances the efficiency of CD1c+ dermal dendritic cells (DDCs) at inducing allogeneic naive CD4+ T-cell proliferation and secretion of cytokines. Purified migratory Langerhans cells (LCs) or CD1c+DDCs were treated with cytotoxic T...
cells. CD1c/BDCA-1 is expressed by dendritic cells and B cells, where it traffics between endosomes and the plasma membrane. Heterodimerization with beta-2-Microglobulin is required for CD1c membrane trafficking. CD1c is thought to present a wide variety of lipids to T cells and has been ...
Description: This L161 monoclonal antibody detects CD1c (also known as BDCA-1), a glycoprotein that is noncovalently linked to beta-2 microglobulin on thymocytes and antigen presenting cells such as dendritic and Langerhans cells. This molecule is also expressed on some circulating and marginal zo...