Understanding the ontogeny of conventional dendritic cells (cDCs) is a major aim in the field. The fate of progenitors of the recently described subsets of mouse cDC2s (cDC2A and cDC2B) is determined in the bone marrow. Charles-Antoine Dutertre ...
Since Batf3 overexpression may inhibit adipogenesis by acting directly on adipocytes [29], we investigated whether the presence or loss of Batf3 in BM-derived cells prevents or promotes weight gain and adiposity, respectively, in this setting. First, we reconstituted cDC1s in sublethally irradiated...
(iNKT)cells.Accordingly,among antigen-presenting cells,cDC1s exhibited notable induction of IFN-纬production by iNKT cells,which plays a metabolically protective role in lean adipose tissue.Flt3L treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in...
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have...
Our understanding of conventional dendritic cell (cDC) development and the functional specializations of distinct subsets in the peripheral tissues has increased greatly in recent years. Here, we review cDC development from the distinct progenitors in the bone marrow through to the distinct cDC subsets...
and genetic studies to identify bona fide murine and human CD103+ conventional dendritic cell (cDC)1s, CD11b+ cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34+ cells, respectively. After myocardial infarction (MI), the ...
Myocarditis-induced cDC dynamics occurred in the context of a complex innate immune response in which myeloid cells increased dramatically in the myocardium, peaking on day 7 (Figures 5E and 5F). This was driven by an inflammatory response predominated by the recruitment of Ly6chiMHC-IIloCD64lo...
Here, we report that type 1 conventional dendritic cells (cDC1s), which are defined by expression of CD8α in the mouse and XCR1 and CLEC9 in humans, are critical for induction of erythropoiesis in response to stress. Specifically, using murine models, we determined that engagement of a ...
Conventional dendritic cells (cDC) are professional antigen-presenting cells that induce immune activation or tolerance. Two functionally specialised populations, termed cDC1 and cDC2, have been described in humans, mice, ruminants and recently in pigs. Pigs are an important biomedical model species ...
REVIEW Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues D Sichien1,2, BN Lambrecht1,3,4, M Guilliams1,2 and CL Scott1,2 Our understanding of conventional dendritic cell (cDC) development and the functional specializations of...