在血液中,除了骨髓树突细胞外,一小部分静息B细胞表达CD1c(BDCA-1)。因此,CD1c(BDCA-1)+树突细胞分离试剂盒包括CD19微珠,用于在富集CD1c(BDCA-1)+骨髓树突细胞之前去除B细胞。为了区分CD1c(BDCA-1)+与CD141(BDCA-3)+骨髓树突细胞,它们被指定为1型髓样树突细胞(MDC1s)或常规DC2细胞(cDC2s)。
Talimogene laherparepvec (T-VEC) induces immunogenic cell death, thereby providing maturation signals and enhancing the release of tumor antigens that can be captured and processed by CD1c (BDCA-1)+ / CD141 (BDCA-3)+ myDCs, in order to reinvigorate the cancer-immunity cycle. Methods In ...
and instead produced high levels of the anti-inflammatory cytokine IL-10 and regulatory molecules IDO and soluble CD25. Moreover, E. coli-activated CD1c(+) DCs suppressed T-cell proliferation in an IL-10-dependent manner. Contrary to their mouse CD8(+) DC counterparts, human CD141(+) DCs...
Peripheral blood dendritic cell subset analysis. D Mason (Ed.), Leucocyte Typing VII, Oxford University Press, Oxford (2002), pp. 315-319 Google Scholar 18 M Haniffa, A Shin, V Bigley, et al. Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse ...
FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo. J Immunol. Feb 15;192(4):1982-9. doi: 10.4049/jimmunol.1302391. Epub 2014 Jan 22.Ding Y, ... Vuckovic,Khalil,O'Keeffe,... - 《Journal of Immunology Off...
CD1a is also expressed on Langerhans cells and CD1c in a subset of B cells [5]. CDl-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity He, "Human yd T cell recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells," Biology Direct, vol. ...
Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not no...
Background The presence of CD1c (BDCA-1)+ (cDC2) and CD141 (BDCA-3)+ (cDC1) conventional dendritic cells (myDC) in the tumor microenvironment (TME) is a necessary prerequisite to induce an effector CD8+ T cell response and for response to immune checkpoint blockade (ICB).1-4 AS01B...
Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease. Am J Physiol Renal Physiol (2013) 305:F1391-401. doi:10.1152/ ajprenal.00318.2013...
Background: Myeloid Dendritic Cells (DC) are potent antigen presenting cells that can be subdivided into CD141 and CD1c+ DC. We have previously reported an unacknowledged role for CD141+DC in the IA synovium. However, the identification and function of CD1c+ DC in the IA synovium has yet...