Taken together, these results demonstrate that Bach1 inhibition alleviates oxidative-stress-induced osteoblast apoptosis and dysfunction by enhancing Nrf2/ARE signaling activation, findings that suggest a critical role for the Bach1/Nrf2/ARE regulation axis in osteoporosis progression. Our study suggests ...
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma. Authors - Tian-Yi Jiang View Article human WB Autophagy MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis Authors - Yuji Shiozaki View Article human WB J Exp Clin Cancer Res Lnc AC01...
2]. BACH1 was initially identified as a heterodimerization partner of MafK, which was discovered through a yeast two-hybrid screen [2]. BACH1 is expressed widely and plays an important role in coordinating the transcriptional activation and inhibition of MafK [2].NotI restriction mapping and...
Nontoxic inhibition of glycolysis around the hexokinase step with 2-DG and the HK2 inhibitor lonidamine reduced glycolysis rates and the antioxidant-induced migration of mTN cells and also the basal migration of mTC cells (Figures 7C–7E). 2-DG and lonidamine also reversed BACH1-induced migration...
PTP1B and IR-β upon insulin stimulation and enhances insulin signaling in hepatocytes. Inhibition of PTP1B significantly attenuates BACH1-mediated suppression of insulin signaling in HFD-fed male mice. Hepatic BACH1 knockdown ameliorates hyperglycemia and improves insulin sensitivity in diabetic male ...
6 BTB-CNC homology 1 (Bach1), a transcriptional factor, has always been a key role in response to oxidative stress. Recent some research for Bach1 focuses on the osteoclastogenesis which is induced by Receptor activator of nuclear factor-κB ligand (RANKL). The inhibition of Bach1 attenuates...
in theoxidative stress response. When the cell undergoes oxidative stress, BACH1 is displaced bynuclear factor (erythroid-derived2)-like-2 (Nrf2), as both compete in binding to the MAREs in target genes. BACH1 also plays a rolein cellproliferation and survival, as it regulates several cell ...
2B, the decrease in pGLCRhβ activity caused by SA, and its cancellation by hemin, was similar to that in K562 cells. In contrast, when BALB/3T3 cells were examined, neither the μLCR-dependent activation nor the SA-dependent inhibition of the β-globin gene reporter was observed (Fig. ...
This highlights the importance of fully characterizing the role B-Raf plays in melanoma development, it's cross talk with other signaling pathways and the molecular consequences of B-Raf inhibition. Oxidative stress is the accumulation of reactive oxygen species (ROS), which are synthesized as a ...
et al. Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. Blood 106, 1995–2001 (2005). CAS PubMed Google Scholar DeKoter, R.P. & Singh, H. Regulation of B lymphocyte and macrophage development by graded expression of PU....