Targeting BACH1 normalized glycolysis and prevented antioxidant-induced metastasis, while increasing endogenous BACH1 expression stimulated glycolysis and promoted metastasis, also in the absence of antioxidants. We conclude that BACH1 stimulates glycolysis-dependent lung cancer metastasis and that BACH1 is ...
1. BACH1 Stabilization by Antioxidants Stimulate Lung Cancer Metastasis (通讯单位:卡罗林斯卡医学院) 肿瘤若想快速进展必须克服氧化应激障碍。虽然膳食中添加抗氧化剂或NRF2激活内源性抗氧化剂可以降低氧化应激,促进早期肺癌的进展,其在肿瘤转移中的作用知之甚少。研究表明,长期补充抗氧化剂n -乙酰半胱氨酸和维生素E...
肺癌最致命的方面是转移。2019 年 7 月11 日,Clotilde Wiel 等来自瑞典和美国的研究人员关注在 BACH1 的蛋白质增加糖的摄取和使用,利用内源性或饮食中的抗氧化剂在体内扩散。该研究题为“BACH1 Stabilization by Antioxidants StimulatesLung Cancer Metastasis”发表在前沿一期的 TOP 杂志《Cell》上,该研究为新型肺...
Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation. Circ. Res. 130, 1038–1055 (2022). Article CAS PubMed Google Scholar Wiel, C. et al. BACH1 stabilization by antioxidants stimulates lung cancer metastasis. Cell 178, 330–345.e322 (2019). Article CAS PubMed ...
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;178:330–45 e322. Article CAS PubMed Google Scholar Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, et al. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism...
BACH1 stabilization by antioxidants stimulates lung cancer metastasis Cell, 178 (2019), pp. 330-345 e322 View in ScopusGoogle Scholar [33] E.P. Consortium An integrated encyclopedia of DNA elements in the human genome Nature, 489 (2012), pp. 57-74 Google Scholar [34] K. Ogawa, J. Sun...
Antioxidants stabilize BACH1 to promote lung cancer metastasis, which depends on glycolysis and lactate secretion and is related to high ATP production rates. Small molecules such as 2-DG, lonidamine (a HK2 inhibitor), 3-BP (a GAPDH inhibitor), dichloroacetate (a pyruvate dehydrogenase kinase inhi...
Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-b
1. BACH1 Stabilization by Antioxidants Stimulate Lung Cancer Metastasis (通讯单位:卡罗林斯卡医学院) 肿瘤若想快速进展必须克服氧化应激障碍。虽然膳食中添加抗氧化剂或NRF2激活内源性抗氧化剂可以降低氧化应激,促进早期肺癌的进展,其在肿瘤转移中的作用知之甚少。研究表明,长期补充抗氧化剂n -乙酰半胱氨酸和维生素E...