However, the cardioprotective effects of Bach1 knockdown were reversed by pre-treatment with Zinc Protoporphyrin (ZnPP), a selective inhibitor of heme oxygenase-1(HO-1). Taken together, these findings demonstrated that Bach1 promoted oxidative stress and ferroptosis through suppressing the expression ...
the small molecule 1-piperazineethanol, α-[(1,3-benzodioxol-5-yloxy) methyl] -4-(2-methoxyphenyl) (M2) was identified as an inhibitor of BACH1 and effectively reduced aflatoxin B1-induced oxidative damage [146]. However
However, the cardioprotective effects of Bach1 knockdown were reversed by pre-treatment with Zinc Protoporphyrin (ZnPP), a selective inhibitor of heme oxygenase-1(HO-1). Taken together, these findings demonstrated that Bach1 promoted oxidative stress and ferroptosis through suppressing the expression ...
1c). It is known that Bach1 functions as a transcription inhibitor by binding to the promoter fraction of HMOX1, thereby regulating HMOX1 gene expression. Our chromatin immunoprecipitation-quantitative polymerase chain reaction results showed a significant increase in Bach1 binding to the HMOX1 ...
in theoxidative stress response. When the cell undergoes oxidative stress, BACH1 is displaced bynuclear factor (erythroid-derived2)-like-2 (Nrf2), as both compete in binding to the MAREs in target genes. BACH1 also plays a rolein cellproliferation and survival, as it regulates several cell ...
Fbxo22 Ho1 inhibitor Heme Sorry, something went wrong. Please try again and make sure cookies are enabledReferences Anders et al., 2015 S. Anders, P.T. Pyl, W. Huber HTSeq--a Python framework to work with high-throughput sequencing data Bioinformatics, 31 (2015), pp. 166-169 Google ...
By inhibiting B-Raf V600E with the specific inhibitor, PLX-4032, I found that both frequency of melanosphere formation and melanosphere size decreased significantly in those cell lines that harbor the BRAF V600E activating mutation. By modulating the expression of HMOX1, B-Raf, and Bach1 ...
Bach1deficiency in mice protected pancreatic β-cells from oxidative stress-induced apoptosis28. The globalBach1knockout (KO) exerted hepatoprotective effects in methionine-choline deficient diet mice29. Instead, hepatocyte-specific sirtuin 6 deletion predisposed to non-alcoholic steatohepatitis via ...
In contrast, succinylacetone, an inhibitor of heme synthesis, caused accumulation of Bach1 in murine embryonic fibroblasts, indicating that physiological levels of heme regulated the Bach1 turnover. Polyubiquitination and rapid degradation of overexpressed Bach1 were induced by hemin treatment. HOIL-1,...
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-b