of aging-related genes in ECs of coronary arteries from aged monkeys, which concomitantly showed a downregulation of insulin-dependent signaling26. BACH1 orchestrated the metabolic and oxidative stress responses to palmitate and contributed to palmitate-induced human pancreatic β-cell dysfunction27. In ...
2]. BACH1 was initially identified as a heterodimerization partner of MafK, which was discovered through a yeast two-hybrid screen [2]. BACH1 is expressed widely and plays an important role in coordinating the transcriptional activation and inhibition of MafK [2].NotI restriction mapping and...
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the p53 DNA-b
BACH 1, BACH1, BTB and CNC homolog 1, HA2303 Print datasheet MSDS Validation Data Gallery Filter: AllWBIHC WB analysis of HEK-293 using 14018-1-AP WB result of BACH1 antibody (14018-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-BACH1 transfected...
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma. Authors - Tian-Yi Jiang View Article human WB Autophagy MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis Authors - Yuji Shiozaki View Article human WB J Exp Clin Cancer Res Lnc AC01...
Nontoxic inhibition of glycolysis around the hexokinase step with 2-DG and the HK2 inhibitor lonidamine reduced glycolysis rates and the antioxidant-induced migration of mTN cells and also the basal migration of mTC cells (Figures 7C–7E). 2-DG and lonidamine also reversed BACH1-induced migration...
21,37 Inhibition of Bach1 could increase the expression of HO-1 and suppress osteoclastogenesis.38 Our previous study has found that long-term inflammatory stimulation increased the expression of Bach1 and oxidative stress levels in PDLCs and reduced the production of HO-1. Bach1 inhibition could...
[ A variant creates a potential AHR BS, the latter known to be implicated in repression of E2F interaction with promoter of cell-cycle genes (Marlowe et al. 2004) and of estrogen- receptor (ER) binding to estrogen-responsive elements (Kharat and Saatcioglu 1996), resulting in inhibition ...