2]. BACH1 was initially identified as a heterodimerization partner of MafK, which was discovered through a yeast two-hybrid screen [2]. BACH1 is expressed widely and plays an important role in coordinating the transcriptional activation and inhibition of MafK [2].NotI restriction mapping and...
Inhibition of Heme Oxygenase-1Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment Heme oxygenase-1 (HO-1) is believed to represent a key enzyme for the protection of cells against ``stress.'' Its overexpression in different types of huma... PO Berberat,Z Dambrauskas,A ...
Inhibition of MAPK signaling remarkably restrained lung CSCs growth and CSCs properties induced by Bach1 overexpression. Conclusion:In summary, we imply that Bach1 demonstrates great potential for the treatment of lung cancer metastasis and recurrence via activating CD44 and MPAK signaling....
Pharmacological inhibition of Ho1 suppresses metastasis in a Fbxo22-dependent manner. Human metastatic lung cancer display high levels of Ho1 and Bach1. Bach1 transcriptional signature is associated with poor survival and metastasis in lung cancer patients. We propose that Nrf2 activates a metastatic...
influenceepigenetics, and regulate the growth of cancer cells (PMID: 22875853; PMID: 28889753; PMID: 26787 892).BACH1may act on the same gene in different contexts to repress or activate it (PMID: 8887638). Protocols Product Specific Protocols ...
PTP1B and IR-β upon insulin stimulation and enhances insulin signaling in hepatocytes. Inhibition of PTP1B significantly attenuates BACH1-mediated suppression of insulin signaling in HFD-fed male mice. Hepatic BACH1 knockdown ameliorates hyperglycemia and improves insulin sensitivity in diabetic male ...
Nature Cancerthanks Scott Dixon, Kazuhiko Igarashi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. About this article Cite this article Su, Z., Kon, N., Yi, J.et al.Specific regulation of BACH1 by the hotspot mutant p53R175Hreveals a disti...
Transient complement inhibition plus T-cell immunosuppression induces long-term survival of mouse-to-rat cardiac xenografts. BACKGROUND: The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS: BAL... N, Koyamad...
By probing the relationship between BACH1 function and oxidative stress in airway cells we revealed the importance of BACH1 inhibition in alleviating oxidative stress by HMOX1. Consistent with our results, in keratinocytes activation of HMOX1 by NRF2 required the inactivation of BACH1 [44]. In ...
The primary target of Bach1 inhibition is HMOX1 , which codes for Heme Oxygenase 1 (HMOX1), an enzyme that catalyzes the degradation of heme. While a vast body of literature supports the notion that these cytoprotective proteins are inhibitory of cancer, growing evidence has implicated many of...