Inhibition of heme synthesis enhanced the nuclear accumulation of Bach1, whereas treating cells with hemin resulted in nuclear exclusion of Bach1. While the cadmium-inducible nuclear export signal (NES) of Bach1 was dispensable for the heme response, a region containing two of the heme-binding ...
This inhibition allows β-catenin to accumulate in the cytoplasm and subsequently translocate into the nucleus, where it inversely modulates the expression of Wnt target genes43. During this process, β-catenin is identified as a pivotal element in controlling downstream target genes of the Wnt/β-...
The primary target of Bach1 inhibition is HMOX1 , which codes for Heme Oxygenase 1 (HMOX1), an enzyme that catalyzes the degradation of heme. While a vast body of literature supports the notion that these cytoprotective proteins are inhibitory of cancer, growing evidence has implicated many of...
Inhibition of Heme Oxygenase-1Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment Heme oxygenase-1 (HO-1) is believed to represent a key enzyme for the protection of cells against ``stress.'' Its overexpression in different types of huma... PO Berberat,Z Dambrauskas,A ...
PTP1B and IR-β upon insulin stimulation and enhances insulin signaling in hepatocytes. Inhibition of PTP1B significantly attenuates BACH1-mediated suppression of insulin signaling in HFD-fed male mice. Hepatic BACH1 knockdown ameliorates hyperglycemia and improves insulin sensitivity in diabetic male ...
BACH1 regulates the production of reactive oxygen species, with many of its downstream targets such as heme oxygenase-1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1) (PMID: 12356737; PMID: 15734732) involved in theoxidative stress response. When the cell undergoes oxidative stress, BACH1 is...
Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin BACKGROUND & AIMS: HMG-CoA-reductase-inhibitors (statins) have been shown to interfere with HCV replication in vitro. We investigated the mechanism, requir... W Andrea,K Janine,...
Since others reported previously that oxidative stress represses CFTR expression and function [30] and we show here that BACH1 depletion up-regulates oxidative stress response genes [18], we next asked if BACH1 inhibition in combination with H2O2-mediated oxidative stress would have competitive or ...
[2]. BACH1 is expressed widely and plays an important role in coordinating the transcriptional activation and inhibition of MafK [2].NotI restriction mapping and YAC contig mapping demonstrated that the BACH1 gene is present at 21q22.1, betweenNotI sites LA329 (D21S338) and LL60 (D21S389),...
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J. 21, 5216–5224 (2002). CAS PubMed PubMed Central Google Scholar Smith, E.M. et al. Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. ...