the small molecule 1-piperazineethanol, α-[(1,3-benzodioxol-5-yloxy) methyl] -4-(2-methoxyphenyl) (M2) was identified as an inhibitor of BACH1 and effectively reduced aflatoxin B1-induced oxidative damage [146]. However
Tin mesoporphyrin (SnMP), a competitive heme oxygenase (HO) inhibitor, also induces HO-1 mRNA and protein expression by a mechanism that is not fully understood. We examined whether the induction by SnMP is mediated by a de-repression of Bach1, a transcription factor that suppresses the HO-...
In contrast, the miR-27a-5p inhibitor yielded the opposite results. Meanwhile, transfection with Bach1 small interference RNA obviously upregulated the protein levels of HO-1 and resulted in an increase in Bcl-2 and a decrease in caspase-3 protein levels. Thus, we can conclude that miR-27a...
but not by BACH1 lacking BTB adenoviruses (AdBACH1ΔBTB) (Supplementary Fig.9b). These results suggested that the BTB domain, but not the Bzip domain of BACH1 is essential for repressing the insulin signaling. Because heme oxygenase-1 (HO-1) expression is highly sensitive...
Heme binds to Bach1, inhibiting its DNA binding activity and inducing its nuclear export. We found that hemin further induced the degradation of endogenous Bach1 in NIH 3T3 cells, murine embryonic fibroblasts, and murine erythroleukemia cells. In contrast, succinylacetone, an inhibitor of heme ...
Among postmenopausal women with endocrine-responsive breast cancer, the aromatase inhibitor letrozole, when compared with tamoxifen, has been shown to sign... M Colleoni,A Giobbiehurder,MM Regan,... - 《Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology》 被...
Fbxo22 Ho1 inhibitor Heme Sorry, something went wrong. Please try again and make sure cookies are enabledReferences Anders et al., 2015 S. Anders, P.T. Pyl, W. Huber HTSeq--a Python framework to work with high-throughput sequencing data Bioinformatics, 31 (2015), pp. 166-169 Google ...
By inhibiting B-Raf V600E with the specific inhibitor, PLX-4032, I found that both frequency of melanosphere formation and melanosphere size decreased significantly in those cell lines that harbor the BRAF V600E activating mutation. By modulating the expression of HMOX1, B-Raf, and Bach1 ...
BACH1 regulates the production of reactive oxygen species, with many of its downstream targets such as heme oxygenase-1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1) (PMID: 12356737; PMID: 15734732) involved in theoxidative stress response. When the cell undergoes oxidative stress, BACH1 is...
To investigate the influence of rESWT on the Wnt/β-catenin pathway and subsequent VEGF expression, cells were assigned to either the rESWT group or the rESWT group with DKK-1, a Wnt/β-catenin pathway inhibitor, to compare the expression of Wnt3a, β-catenin, and VEGF. The rESWT group...