Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice. J Physiol Pharmacol. 2009;60(suppl 7):149-154.A. Harusato, Y. Naito, T. Takagi et al., "Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice," Journal of Physiology and Pharmacology, vol...
Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic fatty liver disease (NAFLD). Hepatocyte-s...
2]. BACH1 was initially identified as a heterodimerization partner of MafK, which was discovered through a yeast two-hybrid screen [2]. BACH1 is expressed widely and plays an important role in coordinating the transcriptional activation and inhibition of MafK [2].NotI restriction mapping and...
Bach1 inhibition could reverse the oxidative damage of PDLCs caused by inflammation. Therefore, compounds that targeting Bach1 to alleviate oxidative damage and inflammatory response are thought to possess therapeutic effects on periodontitis and other inflammatory diseases.39 However, there is not one ...
Notably, a higher inducibility of NLRP3 inflammasome activation in response to ATP and nigericin following challenge with lipopolysaccharide (LPS) was observed in BACH1-deficient macrophages compared to wild-type cells. Mechanistically, pharmacological inhibition of mtROS markedly attenuated inflammasome ...
Activation of NRF2 or inhibition of BACH1 are, individually, promising therapeutic approaches for NDs. Compounds with dual activity as NRF2 activators and BACH1 inhibitors, could therefore potentially provide a more robust antioxidant and anti-inflammatory effects, with an overall better neuroprotective ...
BACH1 was a target of miR-145a-5p, and its overexpression abolished the inhibition effect of miR-145a-5p on OGD/R-induced astrocyte injury. Besides, circZfp609 downregulation also relieved the brain injury of MCAO mice through miR-145a-5p/BACH1 axis. Conclusion: Our data showed that circ...
International Journal of Molecular Sciences Article Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction Wen-Hsin Chang 1,2, Philip Thai 1, Jihao Xu 3 ID , David C. Yang 1,3, Reen Wu 1 and Ching-Hsien Chen 3,4,* 1 Department of ...
Also, 635-nm irradiation affect the expression of RANKL, OPG, and proinflammatory cytokines. These results indicate that 635-nm irradiation could reduce the alveolar bone resorption induced by LPS stimulation through the inhibition of COX-2 expression and PGE2 production, the suppression of ...
This inhibition allows β-catenin to accumulate in the cytoplasm and subsequently translocate into the nucleus, where it inversely modulates the expression of Wnt target genes43. During this process, β-catenin is identified as a pivotal element in controlling downstream target genes of the Wnt/β-...