for treating obesity-associated insulin resistance. However, so far, no PTP1B inhibitors entered III phase clinical trials due to the low bioavailability of many potent candidates and the competition effect with T-cell protein tyrosine phosphatase (TCPTP) which has much structural similarity to PTP1...
Antioxidants stabilize BACH1 to promote lung cancer metastasis, which depends on glycolysis and lactate secretion and is related to high ATP production rates. Small molecules such as 2-DG, lonidamine (a HK2 inhibitor), 3-BP (a GAPDH inhibitor), dichloroacetate (a pyruvate dehydrogenase kinase inhi...
To investigate the influence of rESWT on the Wnt/β-catenin pathway and subsequent VEGF expression, cells were assigned to either the rESWT group or the rESWT group with DKK-1, a Wnt/β-catenin pathway inhibitor, to compare the expression of Wnt3a, β-catenin, and VEGF. The rESWT group...
Among postmenopausal women with endocrine-responsive breast cancer, the aromatase inhibitor letrozole, when compared with tamoxifen, has been shown to sign... M Colleoni,A Giobbiehurder,MM Regan,... - 《Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology》 被...