for treating obesity-associated insulin resistance. However, so far, no PTP1B inhibitors entered III phase clinical trials due to the low bioavailability of many potent candidates and the competition effect with T-cell protein tyrosine phosphatase (TCPTP) which has much structural similarity to PTP1...
To investigate the influence of rESWT on the Wnt/β-catenin pathway and subsequent VEGF expression, cells were assigned to either the rESWT group or the rESWT group with DKK-1, a Wnt/β-catenin pathway inhibitor, to compare the expression of Wnt3a, β-catenin, and VEGF. The rESWT group...
NAC is a precursor of GSH, but the increased migration of mTN cells did not depend on new GSH synthesis, as the migration of mTN and also mTC cells was unaffected by the GSH inhibitor buthionine sulfoximine and GSH (Figures S2AB–S2AD). Antioxidants Stabilize BACH1 by Reducing Levels of ...
Antioxidants stabilize BACH1 to promote lung cancer metastasis, which depends on glycolysis and lactate secretion and is related to high ATP production rates. Small molecules such as 2-DG, lonidamine (a HK2 inhibitor), 3-BP (a GAPDH inhibitor), dichloroacetate (a pyruvate dehydrogenase kinase inhi...
‘n’collar protein) homology 1, Bach1 has been regarded as a competitive inhibitor for Nrf2 by intervening and competitively inhibiting the interaction of Nrf2 and antioxidant response element (ARE). This negatively regulates the downstream antioxidant genes including heme oxygenase-1 (Ho-1) and ...