and heart failure caused by increased load or genetic cardiomyopathies, reduce myocardial damage after acute and chronic myocardial infarction, and reduce ... S Sciarretta,M Volpe,J Sadoshima - 《Circulation Research》 被引量: 239发表: 2014年 Autophagy Reduces the Size of Acute Myocardial Infarc...
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485, 251–255 (2012). Article CAS PubMed PubMed Central Google Scholar Tannous, P. et al. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc. Natl Acad. Sci. USA 105, 9745–...
Autophagy is important for maintaining cardiac homeostasis and is a survival mechanism that is upregulated during stress or starvation. Accumulating evidence suggests that dysregulated or reduced autophagy is associated with heart failure and aging. Thus, modulating autophagy represents an attractive future ...
Despite maximum medical and mechanical support therapy, heart failure remains a relentlessly progressive disorder with substantial morbidity and mortality. Autophagy, an evolutionarily conserved process of cellular cannibalization, has been implicated in virtually all forms of cardiovascular disease. Indeed, its...
Autophagy-Inflammasome Interplay in Heart Failure:A Systematic Review on Basics,Pathways,and Therapeutic Perspectives. Chiu B,Jantuan E,Shen F,et al. ... B Chiu,E Jantuan,S Fan,... - 《Annals of Clinical & Laboratory Science》 被引量: 2发表: 2017年 Innate immunity of plants: basal defe...
Mitochondrial dysfunctions have been proved to contribute to various heart diseases, especially ischemia reperfusion injury [25], diabetic cardiomyopathy (DCM) [26], pressure-overload induced cardiac hypertrophy and heart failure (HF) [27]. In the failing heart of experimental animals and humans, ...
Heart failure Ischemia/reperfusion 1. Introduction Macroautophagy (further referred to as autophagy) is a dynamic and highly regulated process of self-digestion. The hallmark of autophagy is the de novo formation of autophagosomes, which are double-membrane vacuoles originating from a largely undefined...
BACKGROUND AND AIMS. Almost 30% of survivors of myocardial infarction (MI) develop heart failure (HF), in part due to damage caused by the accumulation of ... L Ai,DFG Juliana,C Huang,... - 《European Heart Journal》 被引量: 0发表: 2024年 Current Perspectives of Mitochondria in Sepsis...
Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.关键词: autophagy cancer endocytosis heart liver PIK3C3 PtdIns3K PtdIns3P Vps34 ...
Taken together, our results indicate that Vps34 plays an essential role in regulating functional autophagy and is indispensable for normal liver and heart function. 展开 关键词: LC3, SQSTM1/p62, 3-MA, epidermal growth factor receptor, transferrin ...