Cardiovascular disease (CVD) is the leading cause of death and the prevalence of CVD dramatically increases with age. Cardiac aging is associated with hypertrophy, fibrosis, inflammation, and decreased contractility. Autophagy, a bulk degradation/recycli
Cardiovascular disease (CVD) is the main cause of morbidity and mortality and the prevalence increases dramatically with age. The prevalence of heart failure in the young adult population (20–39 years old) is less than 1%, but this rises to ~15% among persons 80 years or older [1]. Agin...
Autophagy is very important for your overall health and cardiacautophagyis beneficial for your cardiac health. According to a 2012 scientific review published inHeart Failure Reviews, autophagy plays a beneficial role in heart health, includingin the setting of cardioprotection, hypertrophy, and heart f...
In the field of heart disease, autophagy has been examined in the settings of ischemia and reperfusion, preconditioning, cardiac hypertrophy, and heart failure. This review addresses the role of autophagy in cardioprotection, the balance of catabolism and anabolism, the concept of mitochondrial quality...
Autophagy is an endogenous protective process; the loss of autophagy could destabilize proteostasis and elevate intracellular oxidative stress, which is critically involved in the development of cardiac hypertrophy and heart failure. Oridonin, a natural tetracycline diterpenoid from the Chinese herb Rabdosia...
Autophagy is an intracellular bulk degradation process for proteins and organelles. In the heart, autophagy is stimulated by myocardial ischemia. However, ... Y Matsui,H Takagi,X Qu,... - 《Circulation Research》 被引量: 2607发表: 2007年 Cardiac autophagy is a maladaptive response to hemodynami...
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This complex finally contributed to Drp1 phosphorylation resulted in mitophagy activation and cardioprotection during glucose deprivation and hypoxia/ischemia conditions [3]. Taken together, the protective mitophagy during energy stress in the heart was distinct from canonical autophagy and dependent on Ulk1...
Urolithin A induces cardioprotection and enhanced mitochondrial quality during natural aging and heart failure. bioRxiv. 2023. https://doi.org/10.1101/2023.08.22.554375. Article PubMed PubMed Central Google Scholar Barth S, Glick D, Macleod KF. Autophagy: assays and artifacts. J Pathol. 2010;...
2. Metabolism and autophagy 3. Autophagy in the heart 4. Role of autophagy in common heart diseases 5. Therapies targeting cardiac autophagy to promote cardioprotection 6. Beyond mTOR phosphorylation: taking a mechanistic look at post-translational regulation of autophagy by ubiquitin 7. Direct regula...