Autophagy is a process used for intracellular digestion of organelles and proteins and has special relevance to the long-lived cardiomyocytes in heart disease. The pathway for autophagy and all its mediators remain to be elucidated, but involve such proteins as Atg, Beclin-1, LAMP-2, BH3, Bcl...
Impaired autophagic machinery is implicated in heart disease, which still remains one of the leading causes of mortality and morbidity worldwide. Although basal levels of autophagy are required for cardiomyocyte survival, dysregulation of autophagy has been linked to a change in susceptibility to cell ...
Mitophagy in ischemic heart disease: molecular mechanisms and clinical management Shujuan Xu ,Zihan Wang &Jianhua Fu Article 18 December 2024|Open Access LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1 ...
In this chapter, we briefly review prominent mouse models useful in the study of load鈥恑nduced heart disease and standard techniques used to assess whether a molecular or cellular event is adaptive or maladaptive. We then outline methods available for monitoring autophagic activity in the heart, ...
美[ɔ'tɑfədʒɪ] 英[ɔ:'tɑfədʒɪ] n.细胞自噬作用;〔生化〕自体吞噬;自体消瘦;自身消耗 网络自吞噬;自我吞噬 英汉 网络释义 n. 1. 细胞自噬作用 2. 〔生化〕自体吞噬 3. 自体消瘦 4. 自身消耗 5. 自食 释义: 全部,细胞自噬作用,〔生化〕自体吞噬,自体消瘦,自身消耗,自吞噬,...
Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage Curr. Mol. Med., 14 (5) (2014), pp. 616-629 CrossrefView in ScopusGoogle Scholar [26] M.R. Zeglinski, A.R. Moghadam, S.R. Ande, K. Sheikholeslami, P. Mokarram, Z. Sepehri, H. Rokni, N.K. Mohtar...
Advanced age is associated with a disproportionate prevalence of cardiovascular disease (CVD). Intrinsic alterations in the heart and the vasculature occur... Marzetti,Emanuele,Csiszar,... - 《American Journal of Physiology Heart & Circulatory Physiology》 被引量: 118发表: 2013年 Role of mitochondr...
Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles...
focusing especially on the heart. They also identify significant areas where understanding of Rubicon’s regulatory effects is lacking. Some molecules that interfere with Rubicon’s activity have already been identified. Further research could yield new treatments for heart disease and other conditions. ...
Background and Objectives: Although originally described as a survival mechanism against stressful events, such as starvation, whether and to what extent autophagy is implicated in the terminal stages of heart failure is unknown. Hence, we studied magnitude and evolution of autophagy in patients with...