heart diseasemetabolismischemiafluxcell deathImpaired autophagic machinery is implicated in heart disease, which still remains one of the leading causes of mortality and morbidity worldwide. Although basal levels of autophagy are required for cardiomyocyte survival, dysregulation of autophagy has been linked...
Mitophagy in ischemic heart disease: molecular mechanisms and clinical management Shujuan Xu , Zihan Wang & Jianhua Fu Article 18 December 2024 | Open Access LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1 Yancheng Zhong , Yang ...
Impaired autophagic machinery is implicated in heart disease, which still remains one of the leading causes of mortality and morbidity worldwide. Although basal levels of autophagy are required for cardiomyocyte survival, dysregulation of autophagy has been linked to a change in susceptibility to cell ...
美[ɔ'tɑfədʒɪ] 英[ɔ:'tɑfədʒɪ] n.细胞自噬作用;〔生化〕自体吞噬;自体消瘦;自身消耗 网络自吞噬;自我吞噬 英汉 网络释义 n. 1. 细胞自噬作用 2. 〔生化〕自体吞噬 3. 自体消瘦 4. 自身消耗 5. 自食
In this chapter, we briefly review prominent mouse models useful in the study of load鈥恑nduced heart disease and standard techniques used to assess whether a molecular or cellular event is adaptive or maladaptive. We then outline methods available for monitoring autophagic activity in the heart, ...
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Advanced age is associated with a disproportionate prevalence of cardiovascular disease (CVD). Intrinsic alterations in the heart and the vasculature occur... Marzetti,Emanuele,Csis...
Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles...
Autophagycovers the following topics: autophagic processes (i.e. the lysosome/vacuole dependent degradation of intracellular material); the connections between autophagy and various aspects of human health and disease including, cancer, neurodegeneration, aging, diabetes, myopathies and heart disease; and...
focusing especially on the heart. They also identify significant areas where understanding of Rubicon’s regulatory effects is lacking. Some molecules that interfere with Rubicon’s activity have already been identified. Further research could yield new treatments for heart disease and other conditions. ...
Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage Curr. Mol. Med., 14 (5) (2014), pp. 616-629 CrossrefView in ScopusGoogle Scholar [26] M.R. Zeglinski, A.R. Moghadam, S.R. Ande, K. Sheikholeslami, P. Mokarram, Z. Sepehri, H. Rokni, N.K. Mohtar...