While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In ...
Cardiac autophagy is decreased with age, and misfolded proteins and dysfunctional mitochondria are accumulated in the aging heart. Inhibition of autophagy leads to exacerbated cardiac aging, while stimulation of autophagy improves cardiac function and also increases lifespan in many organisms. Thus ...
Autophagy in Disease and Aging Summary This chapter contains sections titled: Introduction Autophagy in Neurodegenerative Disorders Protein Misfolding and Aggregation Parkinson's Disease... Deretic,Vojo - Wiley‐VCH Verlag GmbH & Co. KGaA 被引量: 4发表: 2006年 Heart-Specific Activin Signaling Promotes...
In addition, autophagy plays a role in development, aging and immunity [4], [5], [6]. 2. Autophagy in the normal heart and in heart disease One of the first reports that described autophagy in the heart was published in the mid 1970s, one decade after the initial description of ...
Autophagy in stem cell maintenance and differentiation. Stem Cells Dev 2012; 21: 513–520. CAS PubMed Google Scholar Garcia-Prat L, Sousa-Victor P, Munoz-Canoves P . Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells. FEBS J 2013 e-pub ahead of ...
Accumulating evidence suggests that dysregulated or reduced autophagy is associated with heart failure and aging. Thus, modulating autophagy represents an attractive future therapeutic target for treating cardiovascular disease. Activation of autophagy is generally considered to be cardioprotective, whereas ...
In mice, it also postpones the manifestation of various age-associated disorders such as cardiovascular disease and neurodegeneration. The specific features of spermidine, including its presence in common food items, make it an interesting candidate for translational aging research. Here, we review ...
The global population is aging. Cardiovascular disease is the leading cause of death in both men and women older than 65 years. In particular, elderly pati... David,Leibowitz - 《Cardiorenal Medicine》 被引量: 10发表: 2014年 The cardiorenal volume index: a simple biochemical algorithm for the...
Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 24, 92–104 (2014). Article CAS PubMed Google Scholar Green, D. R., Galluzzi, L. & Kroemer, G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333, 1109–1112 (2011). Article ...
In mice, it also postpones the manifestation of various age-associated disorders such as cardiovascular disease and neurodegeneration. The specific features of spermidine, including its presence in common food items, make it an interesting candidate for translational aging research. Here, we review ...