While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In ...
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival.
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intr...
autophagy in agingIntroductionAutophagy in Neurodegenerative Disorders Protein Misfolding and AggregationParkinson's DiseaseAlzheimer's DiseaseHuntington's DiseasePrion DiseasesNiemann–Pick Type CAutophagy and Cancer Proteolysis of long-lived Proteins and Effect of Nutrient Deprivation in Cancer CellsAutophagic ...
Autophagy in healthy aging and disease Article 12 August 2021 Autophagy and autophagy-related pathways in cancer Article 02 March 2023 Autophagy: Regulator of cell death Article Open access 04 October 2023 References Klionsky DJ. The molecular machinery of autophagy: unanswered questions. J Cell ...
Autophagy in healthy aging and disease. Nat. Aging 1, 634–650 (2021). Article Google Scholar Pyo, J.-O. et al. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat. Commun. 4, 2300 (2013). Article Google Scholar Bjedov, I. et al. Fine-tuning autophagy ...
In neurons, the maintenance of efficient proteostasis is essential to healthy aging since the dysregulation of the proteostasis network can lead to neurodegenerative disease. Each of these brain pathologies is characterized by the repeated misfolding of one of more peculiar proteins, which evade both ...
In healthy cells,autophagy provides a routine “garbage disposal” service to cells, eliminating damaged components that could otherwise become toxic. When cells are in starvation, autophagy will provide a nutrient source ro promot survival. From the characteristics above, it is easy to conclude that...
Autophagy in healthy aging and disease. Nat. Aging 1, 634–650 (2021). Article Google Scholar Pyo, J.-O. et al. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat. Commun. 4, 2300 (2013). Article Google Scholar Bjedov, I. et al. Fine-tuning autophagy ...
Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J., & Fang, E. F. (2021). Autophagy in healthy aging and disease.Nature Aging,(8), 634–650.https://doi.org/10.1038/s43587-021-00098-4...