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Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol Mech Dis 2013; 8:105-137. 11 Nixon RA. The role of autophagy in neurodegenerative dis- ease. Nat Med 2013; 19:983-997. 12 Haack TB, Hogarth P, Kruer MC, et ...
Multiple ways of search was provided in this website. You can choose more than one way to find the message you need exactly. If you are not very familar with this aspect, content below give the brief introduction of the autophagy as well as the relationship between autophagy and human dise...
University of Tokyo, Tokyo (N.M.); and the Center for Autophagy Research, Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas (B.L.). Address reprint requests to Dr. Mizushima at the Department of Biochemistry and...
Autophagy and human disease Here, we review the major advances in identification of mutations or polymorphisms of thegenes in human diseases. Current autophagy-modulating compounds in clinical trials are also summarized.高村,聡人... 高村,聡人,水島,昇 - 《Cell》 被引量: 23发表: 2008年 Understand...
Aiming to expand the therapeutic potential of autophagy, many researchers focus on developing new drugs or treatment strategies for Parkinson's disease, rheumatic diseases and oncogenesis by controlling cell fate via regulating molecular pathways. This series aims to highlight essential molecular and ...
Autophagy publishes research on autophagic processes, to advance understanding of the connection between autophagy and human health and disease.
Asthma is a chronic inflammation of the airways that presents itself most commonly as episodes of wheezing, shortness of breath, chest tightness and coughing. Approximately 300 million people worldwide suffer from this disease [32]. Because autophagy is implicated in immune responses and inflammation...
The coordinated activity of these cells is essential to ensuring bone homeostasis as disturbances to this equilibrium can lead to disease (Table 1). Autophagy is one process that has been shown to be essential for maintaining this balance and for regulating bone and cartilage cell differentiation, ...
(Tsukada and Ohsumi, 1993), the role of autophagy in various human disease states was unclear, and only in the past decade has the connection between autophagy and human disease become the subject of intense study. To date, autophagy has been linked to a growing list of diseases, and it ...