Here we show that genetically impairing autophagy within the major learning-related brain-center of Drosophila, called mushroom body (MB), sufficed to trigger brain-wide changes in presynaptic organization in a non-cell autonomous manner. The occurrence of this brain-wide presynaptic metaplasticity was...
Recent studies have shown the existence of autophagy in cerebral ischemia; however, there has been no research on the role of autophagy in cerebral injury after cardiopulmonary resuscitation (CPR). This study was conducted to determine the role of autophagy in an animal model of ventricular fibrilla...
Starvation increases the number and size of autophagosomes in many tissues, suggesting that autophagy is a critical component of the body's response to nutrient deprivation and amino acid/fuel homeostasis. In addition, autophagy has been shown to play a critical role in maintaining amino acid and...
Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular components are selectively digested for the recycling of nutrients and energy. This process is indispensable for cell homeostasis maintenance and stress responses. Both genetic and functional studies have demonstrated tha...
When Wnt signaling is activated, β-catenin acts as a corepressor of one of the autophagy proteins, p62. In contrast, another key Wnt signaling protein, GSK3β, negatively regulates the Wnt pathway and has been shown to induce autophagy by phosphorylation of the TSC complex. This article ...
In fact, the biodistribution and accumulation of nanosized plastic particles have been evaluated by oral administration of fluorescent polystyrene nanoparticles (PS-NPs) (Amereh et al., 2020). By using a whole-body-scanning system, the highest fluorescence intensity was observed in the testes ...
From a hitherto underappreciated phenomenon, autophagy has become one of the most intensively studied cellular processes in recent years. Its role in cellular homeostasis, development and disease is supported by a fast growing body of evidence. Surprisingly, only a small fraction of new observations ...
Tan IIA promoted autophagic body production and increased autophagy-associated protein beclin-1 and LC3-II expression in A375 cells. However, Tan IIA reduced the phosphorylation of PI3K, P-AKT, P-mTOR, and P-p7036k1. We also confirmed that Tan II A reduced melanoma A375 induced tumor ...
Caspases are cysteine proteases with essential functions in the apoptotic pathway; their proteolytic activity toward various substrates is associated with the morphological changes of cells. Recent reports have described non-apoptotic functions of caspases, including autophagy. In this report, we searched ...
Effects of DEHP and HD on Body Weight and Lipid Levels in Rats The body weight of rats on both diets increased with exposure time (Figure 1A, B). As differences were not found in body weight, lipids, or hormones between male and female rats, the sex was combined for analysis in the...