Exercise induces autophagy in peripheral tissues and in the brain . Autophagy 8 : 1548 – 1551 .He C, Sumpter R, Jr, Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy. 2012; 8 :1548–1551.He C, Sumpter R, Jr., Levine B. Exercise induces autophagy...
The present study aimed to investigate the activation of Atg1/pULK, and LC3 in the cerebral cortex following focal cerebral ischemia reperfusion (CIR) injury, thereby examining its effect on autophagy in brain cells. Rat CIR models were established using the technique of middle cerebral artery occl...
23. Nixon RA. Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease. FASEB J 2017;31:2729-2743. 24. Jelani M, Dooley HC, Gubas A, et al. A mutation in the major autophagy gene, WIPI2, associated with global ...
is the primary cause of blindness worldwide. Senile cataract usually occurs in elderly people over 50 years of age and is the result of gradual opacification of the lens, an important part of the eye’s optical system [9] (Fig. S1). The lens epithelial cells (LECs), the only...
Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/re-profile existing compounds used in humans to identify those that may induce autophagy in the brain. A key challenge with this approach...
Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for fr... Ana,Lopez,Suzee,... - 《Brain》 被引量: 16发表: 2017年 Upregulation of autophagy-related gene 5 protects dopaminergic neurons in...
Expression of the essential autophagy-related protein 5 (Atg5), which supports T lymphocyte survival and proliferation, is increased in T cells isolated from blood or brain tissues from patients with relapsing-remitting MS. Whether Atgs contribute to the activation of autoreactive T cells through ...
Sylvian fissure morphology and asymmetry in men and women: bilateral differences in relation to handedness in men. The anatomy of the sylvian fissure in the human brain was studied to develop reliable criteria for anatomical landmarks of the posterior part of the fissur... SF Witelson,DL Kiga...
The meaning of AUTOPHAGY is the biological process that involves the enzymatic breakdown of a cell's cytoplasm or cytoplasmic components (such as damaged or unneeded organelles or proteins) within the lysosomes of the same cell. How to use autophagy in a
Autophagy, mitochondria and cell death in lysosomal storage diseases. Cell death is well documented in parts of the brain and in other cells of LSD patients and animal models, although little is known about mechanisms by... K Kiselyov,JJ Jennings,Y Rbaibi,... - 《Autophagy》 被引量: 298...