The Science: Autophagy What is it? Autophagy is the removal of damaged components within the cell to maintain and improve health. How does it work? Autophagy creates autophagosomes that capture and degrade damaged cellular components. Why is it important? Autophagy is a quality control system that...
In simple terms, T24 and EJ cells were lysed in RIP lysates and incubated with magnetic beads containing antibodies specifically recognizing VCP proteins. IgG was used as a negative control. RNA samples bound to the magnetic beads were eluted as RT templates, and the relative content of circHIP...
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Ali et al. Molecular Medicine (2023) 29:142 https://doi.org/10.1186/s10020-023-00742-2 Molecular Medicine REVIEW Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator Open Access Naif H. Ali1†, Hayder M. Al-kuraishy2†, Ali I. Al-Gareeb2, Saud ...
Common regulatory pathways in both ferroptosis and autophagy Even though strong links exist between ferroptosis and autophagy, the relationship between them is more than a simple positive or negative correlation, different regulatory mechanisms emerge depending on the situation. Therefore, finding the common...
· Hannu Kalimo Published online: 4 February 2015 © Springer-Verlag Berlin Heidelberg 2015 Christian de Duve discovered lysosomes [8] by "Exploring Cells with a Centrifuge" as was the title of his Nobel lec- ture when he in 1974 received the Nobel prize in Physiol- ogy and Medicine...
Here, we provide a detailed description of a simple assay for quantitatively monitoring glycolysis and mitochondrial respiration in cultured cancer cells that mount an adaptive autophagic response to stress. In this setting,flux analysisis employed to measure extracellular acidification rate (ECAR) as an...
Indeed, intracytoplasmic amyloidogenesis might, in specific ways, be a component system in production of both synapse loss and neuronal cell death largely in terms of the etiologic cause of the amyloidogenesis as a prototype of cellular degeneration in its own right. It might perhaps be relevant...
In plants, autophagy is a conserved process by which intracellular materials, including damaged proteins, aggregates, and entire organelles, are trafficked
Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established auto