Accumulating evidences suggest that the activity of autophagy decreases with age, whereas several interventions which induce activation of autophagy promote longevity and prevents age-related diseases. Here we summarize recent progress regarding the role of autophagy in animal aging and life span regulation...
The Role of Autophagy in Aging: Its Essential Part in the Anti-Aging Mechanism of Caloric Restriction Healthy Aging and Longevity 1114: 69-78.Bergamini E, Cavallini G, Donati A, Gori Z.The role of au- tophagy in aging: its essential part in the ... E Bergamini,G Cavallini,A Donati,...
W. AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Rep. 8, 1767–1780 (2014). Article PubMed PubMed Central CAS Google Scholar Fernandez, A. F. et al. Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Nature 558,...
Figure 1. Hypothetical modes of genetic and pharmacologic manipula tions in the regulation of longevity and autophagy. Sirtuin 1 is a nicotina mide adenine dinucleotide (NAD+)-dependent deacetylase that can be activated by caloric restriction, by depletion of its negative regulators (such ...
W. AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Rep. 8, 1767–1780 (2014). Article PubMed PubMed Central CAS Google Scholar Fernandez, A. F. et al. Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Nature 558,...
is crucial for the longevity of long-lived mutant roundworms. “From then on, the view that 'autophagy is the key mechanism for extending lifespan' is particularly hot.” Beth Levine explained, “As we grow older, the cell's autophagic capacity will decline, which may lead to aging.” ...
However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains ... Z Liu,L Tao,L Ping,... - 《Oxidative Medicine & Cellular Longevity》 被引量: 26发表: 2015年 Protein Turnover in Aging and Longevity ...
Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev. 2010;3(3):168e77... EE Essick,S Flora - 《Oxidative Medicine & Cellular Longevity》 被引...
Adult lifespan is significantly reduced in ATG-18 mutant animals, demonstrating that longevity as such is crucially determined by essential autophagy factors. In this review we summarize the role of WIPI proteins and their C. elegans homologues with regard to the molecular basis of aging. As the...
These findings suggest that the autophagy gene cascade functions downstream of and is inhibited by different longevity pathways in C. elegans, therefore, their effects converge on autophagy genes to slow down aging and lengthen life span. Thus, autophagy may act as a central regulatory mechanism of...