There are many important factors involved in UPS and autophagy but this systematic review shows the studies that have mostly focused on the role of ATG, 20s proteasome and mTOR in CRC, and the more important factors such as ATG8, FIP200, and TIGAR factors that are effective in the ...
In this Review we aim to synthesize an integrated perspective of the many disparate findings regarding YAP and TAZ in cancer. We then conclude with the various strategies for targeting and treating YAP- and TAZ-dependent cancers. This is a preview of subscription content, access via your ...
Nature Reviews Drug Discovery thanks Bridget Wagner, Jeremy Jenkins and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutio...
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This study aims to shed light on the most impactful therapeutic strategies in the context of GC immunotherapy, highlighting both established and emerging approaches. Main body This review examines over 160 clinical studies conducted globally, focusing on the effectiveness of various immunotherapy ...
However, there has been limited research investigating the role ofH. pyloriinfection in carcinogenesis via regulating PD-L1. Previous investigations have largely focused on howH. pylori-induced gastritis and pre-cancerous lesions promote PD-L1 expression. Thus, we will review some of the key findin...
Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis, and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) caused by iron-mediated lipid peroxidation, exhibits cellular, molecular, and gene-level characteristics distinct from other ce...
(iCM-Exos), like cell transplantation, enhances cardiomyocyte survival under hypoxia as well as cardiac function in a mouse myocardial infarction model. They cause transcriptional alterations in the peri-infarct area, namely altering mTOR signaling, and increasing autophagy and autophagic flux. Thus, ...
et al. Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach. Mol Divers 28, 1823–1845 (2024). https://doi.org/10.1007/s11030-023-10634-6 Download citation Received04 January 2023 Accepted16 March 2023 Published28 March 2023 Issue DateJune 2024 DOI...
(iCM-Exos), like cell transplantation, enhances cardiomyocyte survival under hypoxia as well as cardiac function in a mouse myocardial infarction model. They cause transcriptional alterations in the peri-infarct area, namely altering mTOR signaling, and increasing autophagy and autophagic flux. Thus, ...