Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that ...
A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein...
16, 30 NLRP3 can be activated in response to different stimuli (particularly pathogen-associated or damage-associated molecular patterns, some of which can be induced due to cholesterol accumulation, hypoxia or dysregulation in autophagy), and lead to a proinflammatory cytokine shift and cell death ...
Immune checkpoint therapy for cancer encompasses strategies that target these regulatory pathways in order to enhance immunity activity against tumor cells [4,5]. The most broadly studied checkpoints are the inhibitory pathways consisting of cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), program...
Thus, research may be well served by focusing on identifying the pathways, such as changes in autophagy, metabolism, or epigenetic modifications, that drive resistance, rather than on studying single mutated genes. For example, therapy that confers sensitivity to MAPK-pathway inhibition has recently ...
(ATG7), thus it cannot be ruled out that G4 binder effects on neuronal functions are caused by stabilization of DNA/RNA G4s in other genomic loci. Interestingly, the two studied G4 binders showed a different strength in autophagy downregulation [113], suggesting a role for ligand-specific ...
METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However
OPEN QUESTIONS ● How can MSC-derived EVs mediate immunomodulation and regeneration? ● How can MSC-derived EVs be used to aid regeneration of fibrotic tissue? ● How can mass manufacturing of MSC-derived EVs be achieved and the problem of quality heterogeneity overcome? ● What are the ...
Autophagy Mediates Both Tumor Cell Survival and Death Autophagy represents an important cell-physiologic response that, like apoptosis, normally operates at low, basal levels in cells but can be strongly induced in certain states of cellular stress, the most obvious of which is nutrient deficiency (...
Questions answered in this articleBetaPowered by GenAIThis is generative AI content and the quality may vary. Learn more. What other benefits were observed in patients receiving MSC-secretome and Extracellular Vesicles (EVs)? How do the administration routes of MSC-secretome and Extracellular Vesicles...