Autophagy is an evolutionarily conserved catabolic process involving the self-degradation of organelles and cytosolic macromolecules. It has been discovered to share a complex and multifaceted functional relationship with apoptosis. Autophagy can either inhibit or enhance apoptotic cell death depending on the...
Autophagy-related protein 8 EGF: Epidermal growth factor EGFR: Epidermal growth factor receptor ERK: Extracellular signal-regulated kinase FASI: Fatty acid synthase I FoxO: Forkhead Box O HFHS: High-fat high-sugar IGF1: Insulin-like growth factor 1 ITT: Insulin tolerance test JAK:...
Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha-synuclein and enhance therapy of Parkinson’s disease. Adv Mater. 2022;34:e2108435. Article PubMed Google Scholar Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: sibling rivals for control...
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria. Cell Death Dis 2015; 6: e1788. Article PubMed PubMed Central CAS Google Scholar Papa L, Gomes E, Rockwell P . Reactive oxygen species induced by proteasome...
Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells. Rheumatol (Oxford). 2014;53(6):1022–33. https://doi.org/10.1093/rheumatology/ket471. Article CAS Google Scholar Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F. Interleukin-1 and tumor necrosis ...
Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes. PLoS One 2015; 10: e0115686. doi: 10.1371/journal.pone.0115686 [6] Saif MW, Shah MM, Shah AR. Fluoropyrimidine-associated cardiotoxicity: revisited...
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation We recently noted that low doses of sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95, and this drug co... MA Park,G Zhang,AP...
Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its mod
autophagy and mitophagy in CSF cells to provide possible insight into DCI pathogenesis. CSF samples were collected from 56 SAH patients (DCI, n = 21; and non-DCI, n = 35). We analyzed CSF cells using autophagy and mitophagy markers (DAPK1, BNIP3L, BAX, PINK1, ULK1, and NDP...
GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection ArticleOpen access18 February 2025 RNA modification in cardiovascular disease: implications for therapeutic interventions Open access27 October 2023 Galactin-8DNA methylation mediates macrophage autophagy through the ...