Open Access Following autophagy step by step TEHT Johansen 被引量: 0发表: 0年 Control of the Autophagy Maturation Step by the MAPK ERK and p38: Lessons from Environmental Carcinogens Macroautophagy (hereafter referred to as autophagy) is the major degradative pathway of long-lived proteins and ...
Promising results have been observed in patients with glioma for over a decade now when autophagy inhibition with chloroquine derivatives coupled with conventional therapy. The application of autophagy inhibitors, the role of immune cell-induced autophagy, and the potential role of novel cellular and ...
Autophagy is a reparative process in which cellular homeostasis is maintained through the lysosomal degradation of dysfunctional cytoplasmic components4. In particular, when healthy mitochondria are maintained though the selective removal of damaged or dysfunctional mitochondria via autophagy, this is referred ...
Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells. Rheumatol (Oxford). 2014;53(6):1022–33. https://doi.org/10.1093/rheumatology/ket471. Article CAS Google Scholar Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F. Interleukin-1 and tumor necrosis ...
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation We recently noted that low doses of sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95, and this drug co... MA Park,G Zhang,AP...
Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes. PLoS One 2015; 10: e0115686. doi: 10.1371/journal.pone.0115686 [6] Saif MW, Shah MM, Shah AR. Fluoropyrimidine-associated cardiotoxicity: revisited...
The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin (CAP), the main component of chili pepper. Despite studies in several neurological diseases, the role of TRPV1 in demyelinating diseases
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–5. Article CAS Google Scholar Tu Y, Guo C, Song F, Huo Y, Geng Y, Guo M, et al. Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and ...
Autophagy and apoptosis, which are important processes for host immunity, are commonly exploited by viruses to facilitate their survival. However, to the best of our knowledge, very few studies have researched the mechanisms of action of the autophagic a
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