Review Article 30 December 2024 | Open Access Mitophagy in ischemic heart disease: molecular mechanisms and clinical management Shujuan Xu , Zihan Wang & Jianhua Fu Article 18 December 2024 | Open Access LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA ...
Autophagycovers the following topics: autophagic processes (i.e. the lysosome/vacuole dependent degradation of intracellular material); the connections between autophagy and various aspects of human health and disease including, cancer, neurodegeneration, aging, diabetes, myopathies and heart disease; and...
Impaired autophagic machinery is implicated in heart disease, which still remains one of the leading causes of mortality and morbidity worldwide. Although basal levels of autophagy are required for cardiomyocyte survival, dysregulation of autophagy has been linked to a change in susceptibility to cell ...
Importantly, these connections are already being exploited to treat patients with dozens of clinical trials that aim to manipulate autophagy to treat (or prevent) disease. This Minireview discusses some of the important issues and problems to be solved if these efforts are to be successful. 展开 ...
heart disease, cancer, metabolic disorder and aging. Jihoon Nah and colleagues at Rutgers New Jersey Medical School, Newark, USA, review the role of Rubicon in health and disease. The authors discuss how Rubicon suppresses autophagy in ways that could promote cell death and disease, focusing ...
Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles...
- 《Circulation Research A Journal of the American Heart Association》 被引量: 55发表: 2015年 therapeutic targeting of autophagy potential and concerns in treating cardiovascular disease downloaded from Orogo A M, Guslafsson A B.Therapeutic targeting of autophagy :potential and concerns in treating ...
In this chapter, we briefly review prominent mouse models useful in the study of load鈥恑nduced heart disease and standard techniques used to assess whether a molecular or cellular event is adaptive or maladaptive. We then outline methods available for monitoring autophagic activity in the heart, ...
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death Article Open access 14 April 2021 Targeting mitophagy in neurodegenerative diseases Article 14 January 2025 References Noda, N. N. & Inagaki, F. Mechanisms of autophagy...
due in large part to the multiple connections between autophagy and various aspects of human health and disease including cancer, neurodegeneration, aging, diabetes, myopathies and heart disease. Our goal is to be the premiere journal in this field, publishing papers that you want read by the ...