The functional role of autophagy during ischemia/reperfusion in the heart is complex. It has also been unclear whether autophagy is protective or detrimental in response to ischemia/reperfusion in the heart. In this review, we will summarize the role of autophagy in the heart under both normal ...
The role of the autophagy in myocardial ischemia/reperfusioninjury. Biochimica et Biophysica Acta (BBA)- Molecular Basis Dis 2015; 1852(2): 271-276.Ma S., Wang Y., Chen Y. & Cao F. The role of the autophagy in myocardial ischemia/reperfusion injury . Biochim Biophys Acta , (2014)....
Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims...
heart disease, cancer, metabolic disorder and aging. Jihoon Nah and colleagues at Rutgers New Jersey Medical School, Newark, USA, review the role of Rubicon in health and disease. The authors discuss how Rubicon suppresses autophagy in ways that could promote cell death and disease, focusing ...
Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells1,2. Although altered autophagy has been observed in various heart diseases, including cardiac hypertr
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. A... A Nakai,O Yamaguchi,T Takeda,... - ...
The role of autophagy in liver cancer has been increasingly studied and appreciated. Disruption of autophagy in the liver will impair the balance of energy and nutrients for basic cell function which could thus have a major impact on liver physiology and liver disease [17], [18], [19]. Ther...
Roles of OGT in autophagy Autophagy is a self-degradative process essential for maintaining cellular homeostasis under stress conditions [151, 152]. Well-known regulatory pathways of autophagy include AMPK, PI3K/Akt/mTOR, and Beclin-1 [153]. Recent studies have highlighted the role of OGT in aut...
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