Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cao Yang,Klionsky Daniel J. Cell Research . 2007Physiological functions of Atg6/Beclin 1:A unique autophagy related protein. Cao Y,Klionsky DJ. Cell Research . 2007...
Autophagy exists widely in eukaryotic cells and is regulated by a variety of molecular mechanisms. Its physiological functions include providing energy, maintaining cell homeostasis, and promoting apoptosis of abnormal cells. At present, the regulation of autophagy in tumor, degenerative disease, and card...
Cardiac pathologies are associated with increased late I-Na that contributes to the dysregulation of ion homeostasis and causes electrical and contractile ... H Toko,Y Kayama,M Sakamoto,... - 《Journal of Molecular & Cellular Cardiology》 被引量: 111发表: 2006年 Functions of Autophagy in Pathol...
CYM Hsu,Uluda?, Hasan - 《Journal of Drug Targeting》 被引量: 30发表: 2012年 Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy i... Despite much interest, the physiological functions of LR...
Molecular NeurodegenerationVetrivel, KS, Zhang, YW, Xu, H, Thinakaran, G (2006) Pathological and physiological functions of presenilins. Mol Neurodegener ... KS Vetrivel,YW Zhang,H Xu,... - 《Molecular Neurodegener...
Consequently, this paper covers the physiological functions of phase separation, their significance for the central nervous system, and the pathological underpinnings of illnesses in the central nervous system. Notably, phase separation could provide researchers with a novel outlook for comprehending and ...
The low-density lipoprotein receptor (LDLR)-related protein (LRP) is a multiligand endocytic receptor that has broad cellular and physiological functions. ... L Melman,HJ Geuze,Y Li,... - 《Molecular Biology of the Cell》 被引量: 106发表: 2002年 Proteasome Dysfunction Activates Autophagy and...
Under the stimulation of atherosclerosis, the initiation of autophagy can prevent fibrosis by reducing the proliferation of arterial smooth muscle cells. The autophagy process is related to autophagosomes (APs) and autophagic flux. Autophagic flux refers to the fusion of lysosomes and APs into mature...
Environmental humidity and water activity are key factors responsible for yeast survival. Water participates in basic cellular functions and is responsible for the stability of cell membranes, DNA, RNA, and proteins. It is necessary for various biochemical reactions, such as enzymatic reactions and hyd...
of protein trafficking, localisation, stability, conformation, interactions and signal transduction by enhancing hydrophobicity. Accumulating evidence from genetic, structural, and biomedical studies has consistently shown that protein lipidation is pivotal in the regulation of broad physiological functions and ...