The initial report on APOE as a susceptibility gene for late-onset Alzheimer's disease was presented a little more than two years ago. During the past year, several significant events have given added impetus to research into Alzheimer's. The association of increased allele frequency of APOE4 ...
A major risk factor for late-onset Alzheimer's type dementia (DAT) is the carriage of the ε4 allele of the apolipoprotein E (ApoE) gene. Identifying cognitive deficits in healthy ApoE-ε4 carriers is valuable in order to develop interve... BB Velichkovsky,IF Roschina,ND Selezneva - 《...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from
Conclusions: Results support that the Aβ overexpression in PMBC can not be significantly influenced by the APOE e4 and polymorphism distribution of PSI gene in AD 展开 关键词: Alzheimer's disease Aβ expression APOE gene PS1 gene 被引量: 5 ...
但这一基因如何造成大脑损伤一直是一个谜。一项研究现已将APOE4和大脑中错误的胆固醇处理联系起来,这会导致围绕神经纤维、促进电活动的髓鞘缺陷。初步结果显示,这些改变可以导致记忆和学习障碍。这项工作还表明,恢复大脑胆固醇处理的药物可提供治疗。 《自然》新闻:This is how an Alzheimer’s gene ravages the brain...
The results were quite remarkable. Children and adolescents who carried the APOE4 allele, the so-called “Alzheimer’s gene,” showed measurably lower scores on verbal, performance and full-scale IQ assessments in comparison to those not positive for this genetic marker. ...
This at home test identifies your APOE gene status with an easy mouth swab instead of a blood test. If you have a variant (APOE4) of the APOE gene, you could be at greater risk of developing late-onset Alzheimer's disease and dementia. Get secure online results and a physician-reviewed...
There are dozens of genes that have been linked to increased Alzheimer’s risk. Some of these genes have just a tiny bit of influence over a person’s likelihood of developing Alzheimer’s; others have quite a lot. One particular gene variant, called APOE4, has accrued a reputation as “...
One of the hallmarks of the brain of an individual with Alzheimer disease is the accumulation of amyloid-beta peptide (A-beta), something that is believed to be toxic to many brain cells (specifically neurons) and to therefore contribute to the underlyin
载脂蛋白E(APOE) 另一个能做到对不同人群“一视同仁”的长寿基因则是APOE。载脂蛋白E基因是一种参与调节脂蛋白转化与代谢的日常基因,却悄悄和衰老挨上了边。 早在1994年的一项针对百岁老人的研究中,APOE就被发现与长寿有关[17]。它可以编码3种常见等位基因ε2、ε3和ε4,而它们功能却大不相同: ...