APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...
Conclusions: Results support that the Aβ overexpression in PMBC can not be significantly influenced by the APOE e4 and polymorphism distribution of PSI gene in AD 展开 关键词: Alzheimer's disease Aβ expression APOE gene PS1 gene 被引量: 5 ...
但这一基因如何造成大脑损伤一直是一个谜。一项研究现已将APOE4和大脑中错误的胆固醇处理联系起来,这会导致围绕神经纤维、促进电活动的髓鞘缺陷。初步结果显示,这些改变可以导致记忆和学习障碍。这项工作还表明,恢复大脑胆固醇处理的药物可提供治疗。 《自然》新闻:This is how an Alzheimer’s gene ravages the brain...
The results were quite remarkable. Children and adolescents who carried the APOE4 allele, the so-called “Alzheimer’s gene,” showed measurably lower scores on verbal, performance and full-scale IQ assessments in comparison to those not positive for this genetic marker. ...
One of the hallmarks of the brain of an individual with Alzheimer disease is the accumulation of amyloid-beta peptide (A-beta), something that is believed to be toxic to many brain cells (specifically neurons) and to therefore contribute to the underlyin
Further studies to clarify this interaction may improve our understanding of the generic risks for AD. Copyright © 2005 S. Karger AG, Basel 展开 关键词: Alzheimer disease Apolipoprotein E Estrogen Estrogen-metabolizing gene polymorphism DOI: 10.1159/000082663 被引量: 45 年份: 2005 ...
There are dozens of genes that have been linked to increased Alzheimer’s risk. Some of these genes have just a tiny bit of influence over a person’s likelihood of developing Alzheimer’s; others have quite a lot. One particular gene variant, called APOE4, has accrued a reputation as “...
(B) Gene Ontology (GO) analysis of genes downregulated at least 2-fold in neurons treated with ADM. (C) The top 30 most decreased genes with a fold change cutoff of 0.5 were visualized in a heatmap. (D and E) mRNA (D) and protein (E) levels of eight cholesterol biosynthetic enzymes...
Keywords: Alzheimer's disease, APOE, Apolipoprotein E, DNA methylation, Cholesterol, Lipids Background The ε4 allele of the apolipoprotein E gene (APOE) is the strongest genetic risk factor for late-onset (> 65 years) Alzheimer's disease (AD) [1–3]. Inheritance of one copy of this ...
These findings suggest the possibility that there might be a gene dose effect, since the age of onset ranged from 5 to 7 years younger in patients who received epsilon 4 alleles from the father. 展开 关键词: Alzheimer Disease Apolipoproteins E Membrane Proteins Mutation 载脂蛋白E类 膜蛋白质...