APOE e4, an Alzheimer's Disease Susceptibility Allele, Predicts Relapse among Older Treatment-seeking Smokers Rebecca L. Ashare*, Jason Karlawish, E. Paul Wileyto, Angela Pinto, Caryn Lerman University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Background: Possessing an ...
Alzheimer’s disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid
longevity in people with Down syndrome resulting in an increased population that may be subjected to many of the same risk factors as those with Alzheimer's disease. It is well established that harboring one or both apolipoprotein E4 alleles greatly increases the risk for Alzheimer's disease. Ho...
“Sex,ApoE4 and Alzheimer's disease:rethinking drug discovery in the era of precision medicine”出自《中国神经再生研究(英文版)》期刊2021年第9期文献,主题关键词涉及有等。钛学术提供该文献下载服务。
阿尔茨海默病(Alzheimer's disease,AD)是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,是老年期痴呆的最常见类型。临床上存在记忆减退、失语、失用、失认等特征,常同时伴随社会或日常生活能力受损和精神行为改变。尽管不同研究提出遗传...
A growing body of research has examined the relationship between episodic memory decline, the cognitive hallmark of Alzheimer's disease (AD), and the presence of Apolipoprotein E ε4 (APOE ε4) allele, a major genetic risk factor for the disease. Our review attempts to summarize and critically...
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among the increasing number of genetic risk factors identified, the apolipoprotein E (APOE) gene remains the strongest and most prevalent, impacting more ...
摘要: apolipoprotein e4 (apoe4) genotype and/or gender do not appear to predict a response to donepezil in patients with mild-to-moderate alzheimer's disease-载脂蛋白E4(ApoE4的)基因型和/或性别没有出现预测患者轻度至中度阿尔茨海默氏病为多奈哌齐响应-知来论文发表中心...
PMI—postmortem interval; MMSE—MiniMental State Exam; CERAD—Consortium to Establish a Registry for Alzheimer's Disease; NFT—neurofibrillary tangle. a n = 54 for this variable. b Fisher's exact test for the distribution of genotypes. For the comparison of APOE*4 carriers versus noncarriers, ...
Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E (APOEε4), the strongest genetic risk factor for late onset Alzheimer’s disease. Beyond its association with late-onset dementia, the association between APOEε4 and change in cognition over the...