2.Korolev IO. Alzheimer’s Disease: A clinical and basic science review. Med Student Res J 2014, 4:24-33. 3.Hung SY, Fu WM. Drug candidates in clinical trials for Alzheimer's disease. J Biomed Sci. 2017;24(1):47. 4.Masters ...
近日,西班牙圣十字圣保罗医院的科研人员在Nature Medicine发表了题为“APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease”的文章。研究团队分析了美国国家阿尔茨海默病协调中心(NACC)的大型病理数据集,以及迄今为止发表的5个大型多中心队列10,039人的AD生物标志物数据。分析结果发现,APOE4...
Member of the European Lilly Advisory Board on Abeta Immunisation studies in Alzheimer's Disease since 2012 Member of the imka connect expert roundtable for in-vivo diagnostics (Amyloid-PET) of AD Lecture Fees: Received lecture fees from Novartis Pharma (2x) and Merz Pharmaceuticals (1x...
近日,来自西班牙巴塞罗那圣十字圣保罗医院的Víctor Montal研究团队在Nature Medicine杂志发表题为APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease的研究论文,该研究利用来自国家阿尔茨海默病协调中心(NACC)的大型病理数据...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating Center ...
[19] Liu, C. C., Liu, C. C., Kanekiyo, T., Xu, H., & Bu, G. (2013). Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature reviews. Neurology, 9(2), 106–118. https://doi.org/10.1038/nrneurol.2012.263 ...
ClinicalTrials数据库提供临床试验APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease的登记号NCT04994847,试验分期以及申办者Banner Health的信息,更过关于临床试验的其他信息查询就在戊戌数据美国临床试验数据库.
ObjectiveThis study aims to explore the relationship between the single nucleotide polymorphism (SNPs) of Apo liporoteine E (ApoE), GTP cyclohydrolase 1 (GCH1), and J subfamily member of inward rectifier potassium channel-15 (KCNJ15) gene and cognitive dysfunction in Han nationality patients with...
Genome-wide association studies (GWAS) have implicated this gene cluster region with multiple phenotypes: lipid traits, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels [1], [2], [3], [4]; late-onset Alzheimer's disease (LOAD), ...
ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus. The ε4 allele of the apolipoprotein E (ApoE) gene may be risk factor of severe peripheral neuropathy in T2DM patients. The association of ApoE ... Tang,...