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The initial report on APOE as a susceptibility gene for late-onset Alzheimer's disease was presented a little more than two years ago. During the past year, several significant events have given added impetus to research into Alzheimer's. The association of increased allele frequency of APOE4 ...
Objective: To clarify the relation between the expression of (3 amyloid protein (Aβ) of APP gene and APOE gene, PSI gene in Alzheimer's disease (AD). Methods: The expression of Aβ in peripheral mononuclear blood cell (PMBC) was examined using semi-quantitative competitive RT-PCR methods ...
APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...
M., Häsler, R., Pallauf, K., Lieb, W., Derbois, C., Galan, P., Drichel, D., … Nebel, A. (2017). Identification and characterization of two functional variants in the human longevity gene FOXO3. Nature communications, 8(1), 2063. https://doi.org/10.1038/s41467-017-02183-y...
《自然》新闻:This is how an Alzheimer’s gene ravages the brain 链接 《自然》论文: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes 链接 图片:来自一名阿尔茨海默症患者的神经元(绿色)有一个不寻常的蛋白复合物(粉色)环绕着细胞核(黄色)。来源:Thomas Deerinck, NCMIR/SPL ...
Genetic association among polymorphism in presenilin 1 gene, ApoE gene and late onset Alzheimer's disease. Chin. J. Nerv. Ment. Dis. 26: 345-348.Ma, C., Li, Q., Fang, R.M.: Genetic association among polymorphism in presenilin 1 gene, APoE gene and late onset A...
Children and adolescents who carried the APOE4 allele, the so-called “Alzheimer’s gene,” showed measurably lower scores on verbal, performance and full-scale IQ assessments in comparison to those not positive for this genetic marker. In discussing the observed IQ difference between APOE 4 ...
There are dozens of genes that have been linked to increased Alzheimer’s risk. Some of these genes have just a tiny bit of influence over a person’s likelihood of developing Alzheimer’s; others have quite a lot. One particular gene variant, called APOE4, has accrued a reputation as “...
P1-309 : Evidence for interaction between the Cholesteryl ester transfer protein (CETP) gene and APOE in late onset Alzheimer’s diseasedoi:10.1016/j.jalz.2006.05.687Alejandro AriasAaron IsaacsYurii AulchenkoAlbert HofmanMonique BretelerBen Oostra...