Introduction: The mechanism behind the strong association between the 2/3/4 apolipoprotein E gene (APOE) polymorphism and Alzheimer's disease is not well-characterized. Because low plasma levels of apoE associate with risk of dementia, genetic variants altering apoE levels in general may also ...
这意味着,有效的 cPLA2 抑制剂可能是一种潜在的治疗方法,可以抑制神经炎症并改善 ApoE4 携带者患者大脑对脂肪酸的摄取。 他们的相关研究发现以 “Lipids and brain inflammation in APOE4-associated dementia” 为题发表于 Current Opinion in Lipidology 期刊。接下来,Hussein Yassine 将与合作团队开发 cPLA2 抑制剂...
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers Alzheimer disease (AD) is characterized by progressive cognitive decline caused by synaptic dysfunction and neurodegeneration in the brain, and late-onset ... NJ Aidaralieva,K Kamino,R Kimura...
Background: Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The ε4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations. ...
https://www.technology.org/2021/03/05/study-offers-an-explanation-for-why-the-apoe4-gene-enhances-alzheimers-risk/ https://www.technology.org/2018/09/21/study-clarifies-proteins-role-in-dementia/ -End- 【往期】 专访丨霍德生物丨「全球新」脑卒中iPSC 专访丨丛乐团队丨高精度千碱基规模基因编辑...
Dementia: Poor lung function in midlife predicts cognitive decline in men lacking APOE ε4New evidence suggests that impaired lung function in midlife is associated with cognitive decline in elderly men who lack the 4 allele of the apolipoprotein E gene (APOE 4), despite previous findings that ...
The common apolipoprotein E (APOE) alleles epsilon2, epsilon3, and epsilon4 are associated with the risk of dementia and cardiovascular disease. Recently, two functional variants (- 219G/T and -491A/T) were identified in the promoter of the APOE gene that enable a further characterization of...
and MACRO (macrophage) marker genes across the 11 subclusters identified in the microglia. HOMEOSTATIC, DAM and LDAM signature scores are shown across the 11 identified subclusters at the bottom.h, UMAP representation of microglia cells indicating the marker gene-based cell state annotation (bottom...
We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Co...
In humans the ApoE gene, particularly the ApoE4 allele, is the major risk factor for the development of Alzheimer's Disease (AD) dementia. The allele's incomplete penetrance indicates that environmental factors play an important part in disease development and, indeed, environmental exposures such ...